Dietary Protein Level Interacts With -3 Polyunsaturated Fatty Acid Deficiency to Induce Hypertension
| Autor: | Denovan P. Begg, Markandeya Jois, Richard S. Weisinger, Manohar L. Garg, Andrew J. Sinclair, Lauren. Stahl |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Aging medicine.medical_specialty Mean arterial pressure food.ingredient Offspring Diastole Blood Pressure Rats Sprague-Dawley food Linseed oil Heart Rate Casein Internal medicine Fatty Acids Omega-3 Internal Medicine medicine Animals chemistry.chemical_classification business.industry Caseins Diet Rats Plethysmography Endocrinology Blood pressure chemistry Hypertension Female Nutrition physiology Dietary Proteins business Polyunsaturated fatty acid |
| Zdroj: | American Journal of Hypertension. 23:125-128 |
| ISSN: | 1941-7225 0895-7061 |
| DOI: | 10.1038/ajh.2009.198 |
| Popis: | Background Dietary omega-3 fatty acid deficiency can lead to hypertension in later life; however, hypertension is affected by numerous other dietary factors. We examined the effect of altering the dietary protein level on blood pressure in animals deficient or sufficient in omega-3 fatty acids. Methods Female rats were placed on one of four experimental diets 1 week prior to mating. Diets were either deficient (10% safflower oil; DEF) or sufficient (7% safflower oil, 3% flaxseed oil; SUF) in omega-3 fatty acids and contained 20 or 30% casein (DEF20, SUF20, DEF30, SUF30). Offspring were maintained on the maternal diet for the duration of the experiment. At 12, 18, 24, and 30 weeks, blood pressure was assessed by tail cuff plethysmography. Results At both 12 and 18 weeks of age, no differences in blood pressure were observed based on diet, however, by 24 weeks hypertension was evident in DEF30 animals; there were no blood pressure differences between the other groups. This hypertension in DEF30 group was increased at 30 weeks, with systolic, diastolic, and mean arterial pressure all elevated. Conclusions These results indicate that the hypertension previously attributed to omega-3 fatty acid deficiency is dependent on additional dietary factors, including protein content. Furthermore, this study is the first to plot the establishment of omega-3 fatty acid deficiency hypertension over time. |
| Databáze: | OpenAIRE |
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