Formulation Optimization of Selective Laser Sintering 3D-Printed Tablets of Clindamycin Palmitate Hydrochloride by Response Surface Methodology
| Autor: | Eman M. Mohamed, Mansoor A. Khan, Tanil Ozkan, Sogra F. Barakh Ali, Mathew Kuttolamadom, Sathish Dharani, Ziyaur Rahman |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Surface Properties Pharmaceutical Science 02 engineering and technology Aquatic Science 030226 pharmacology & pharmacy Dosage form law.invention 03 medical and health sciences chemistry.chemical_compound Crystallinity 0302 clinical medicine Differential scanning calorimetry X-Ray Diffraction law Hardness Drug Discovery Humans Porosity Dissolution Ecology Evolution Behavior and Systematics Ecology Calorimetry Differential Scanning Clindamycin Lasers Clindamycin Palmitate Hydrochloride General Medicine 021001 nanoscience & nanotechnology Anti-Bacterial Agents Microcrystalline cellulose Selective laser sintering chemistry Printing Three-Dimensional 0210 nano-technology Agronomy and Crop Science Nuclear chemistry Tablets |
| Zdroj: | AAPS PharmSciTech. 21(6) |
| ISSN: | 1530-9932 |
| Popis: | The aims of the current study were to develop and evaluate clindamycin palmitate hydrochloride (CPH) 3D-printed tablets (printlets) manufactured by selective laser sintering (SLS). Optimization of the formulation was performed by studying the effect of formulation and process factors on critical quality attributes of the printlets. The independent factors studied were laser scanning speed, microcrystalline cellulose (MCC), and lactose monohydrate (LMH) concentration. The responses measured were printlets weight, hardness, disintegration time (DT), and dissolution in 30 min. The printlets were characterized for content uniformity, chemical interactions, crystallinity, drug distribution, morphology, and porosity. The laser scanning speed showed statistically significant effects on all the studied dependent responses (p |
| Databáze: | OpenAIRE |
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