Comparison of Beta-2 Microglobulin Level and Some Variables Between Thalassemia Major Patients Who Treated by Desferal and Control Group
| Autor: | Azar Aghamohammady, Mandana Zafari |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Kidney Blood transfusion business.industry Beta-2 microglobulin Thalassemia medicine.medical_treatment lcsh:R lcsh:Medicine Urine medicine.disease Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Internal medicine medicine Urea 030212 general & internal medicine Globin Complication business 030215 immunology |
| Zdroj: | Zahedan Journal of Researches in Medical Sciences, Vol 19, Iss 10 (2017) |
| ISSN: | 2383-2894 |
| DOI: | 10.5812/zjrms.11538 |
| Popis: | Background Iron over load will be appearing in kidney following blood transfusion. Desferal as an iron chelator can be ended renal complication. Objectives The aim of this study is evaluation the level of β2 microglobulin in β- Thalassemia major patients for follow up proximal tubular damage. Methods In this descriptive and analytic study 40 thalassemic patients who were treated by Desferal and 40 healthy subjects enrolled in this study randomly. For evaluation the proximal tubular damage in these groups, we measured the β-2 microglobin. Another variable such as: Ca, Mg, P and Urea of blood and K, Cr, protein and volume of urine 24 hours were measured. We compared these variables between two groups. And descriptive and analytic analyses were used. Results The level of β2 microglobulin had significant difference in both groups, also the level of Ca, K and β-2 Globin in serum and Cr, protein and urine volume in 24 houres had significant difference. Conclusions The higher level of β2 microglobulin in Thalassemia major patient who were treated by Desferal, show the proximal tubular damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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