Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin
| Autor: | Maria-Socorro H, Fontoura, César A, Araújo-Neto, Sandra C S, Andrade, Rosa V, Brim, Adriana R, Matutino, Carolina C, Silva, Milena C, Santana, Monalisa, Nobre-Bastos, Felipe, Oliveira, Bruna B, Barreto, Pablo M, Santos, Lúcia, Noblat, Maria-Regina A, Cardoso, Cristiana M, Nascimento-Carvalho, Solange, Carneiro |
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| Rok vydání: | 2010 |
| Předmět: |
Research design
medicine.medical_specialty Pleural effusion Tachypnea Cystic fibrosis Community-acquired pneumonia Internal medicine Pneumonia Bacterial medicine Humans Pharmacology (medical) Adverse effect Pharmacology business.industry Amoxicillin Infant General Medicine medicine.disease Anti-Bacterial Agents Surgery Community-Acquired Infections Pneumonia Treatment Outcome Child Preschool medicine.symptom business medicine.drug |
| Zdroj: | Expert Opinion on Pharmacotherapy. 11:1451-1458 |
| ISSN: | 1744-7666 1465-6566 |
| Popis: | To estimate the clinical failure and adverse events in children with nonsevere pneumonia receiving amoxicillin, identifying risk factors.192 patients aged 2 - 59 months were prospectively followed up. Pneumonia diagnosis was based on respiratory complaints and radiographic pulmonary infiltrate or pleural effusion. Amoxicillin (50 mg/kg/day) was given. Demographic data and clinical findings on admission, daily evolution up to the 5th day of treatment and 2 - 4 weeks after enrollment were collected.Clinical failure included persistence of fever, difficulty breathing or tachypnea beyond the first 48 h of treatment or of cough beyond the first 96 h of treatment or sign of severe/very severe disease up to the 5th day of treatment.Amoxicillin failed in 6 (3.1%) cases. By excluding one child diagnosed with cystic fibrosis after continued follow-up, the final clinical failure rate was 2.6%. The total adverse effect frequency was 14 (7.3%), but amoxicillin was discontinued only in 1 (0.5%) case. No relapse was identified at the 2 - 4-week interval evaluation. By multivariate analysis, age (OR = 1.1; 95% CI 1.01 - 1.19) was an independent risk factor for clinical failure which occurred in older children (47 +/- 9 vs 31 +/- 16 months; p = 0.01).Clinical failures were few, especially among those aged2 years. Amoxicillin discontinuation due to adverse reaction was rare. |
| Databáze: | OpenAIRE |
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