Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil

Autor:	Marco Aurélio Almeida de Oliveira, Luiz Fernando de Souza Passos, Neila Hiraishi Mallmann, Giselle Katiane Bonfim Bacellar de Souza, Marilda Souza Goncalves, Emerson Silva Lima, Domingos Savio Nunes de Lima, José Pereira de Moura Neto, Thiago de Jesus Bacha
Rok vydání:	2021
Předmět:	medicine.medical_specialty Genotype SOD2 Single-nucleotide polymorphism medicine.disease_cause Polymorphism Single Nucleotide 03 medical and health sciences GSTP1 chemistry.chemical_compound 0302 clinical medicine Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease 030212 general & internal medicine Allele Glutathione Transferase 030203 arthritis & rheumatology biology Superoxide Dismutase business.industry Hydrogen Peroxide General Medicine Glutathione Catalase Endocrinology Glutathione S-transferase Glutathione S-Transferase pi chemistry Case-Control Studies biology.protein Female Gene polymorphism business Oxidation-Reduction Brazil Oxidative stress
Zdroj:	Clinical Rheumatology. 40:3639-3649
ISSN:	1434-9949 0770-3198
DOI:	10.1007/s10067-021-05680-0
Popis:	To investigate the frequency of glutathione S-transferase (GST), catalase, and SOD2 genetic polymorphisms and their correlation with SLE. A total of 290 females (patients = 151; controls= 139) were recruited. Multiplex PCR was performed for genotyping GSTM1 and GSTT1 genes, whereas real-time qPCR was used for determination of SNPs: CAT C262T, SOD2 C47T, GSTP1 A313G and GSTP1 IVS6 -C16T. Thiol levels are decreased in SLE patients (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18056e429f9b302773e1fda8b32c83be https://doi.org/10.1007/s10067-021-05680-0 Zobrazit plný text záznamu Full text from SpringerLink