Simple and Efficient Large-scale Metal-free Synthesis of o-(5-Formyl-2-thienyl)benzonitrile and o-(5-Formyl-2-furyl)benzonitrile
| Autor: | Mohamed Majed Tibi, Ivica Cepanec, Marija Lovrić, Mirela Filipan, Mladen Litvić |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Benzonitrile
chemistry.chemical_compound chemistry Metal free 010405 organic chemistry Organic Chemistry Gomberg-Bachmann-Hey reaction o-(5-formyl-2-thienyl)benzonitrile o-(5-formyl-2-furyl)benzonitrile 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Organic molecules |
| Zdroj: | Organic Preparations and Procedures International. 50:81-90 |
| ISSN: | 1945-5453 0030-4948 |
| DOI: | 10.1080/00304948.2018.1405334 |
| Popis: | Modification of the Gomberg-Bachmann-Hey reaction was shown to be the best way for simple and efficient large-scale metal-free synthesis of o-(5-Formyl-2-thienyl)benzonitrile and o-(5-formyl-2-furyl)benzonitrile starting from the respective diazonium salts 2- (methoxycarbonyl)benzenediazonium tetrafluoroborate in thiophene or furan as solvent and reagents. The transformation of the resulting intermediates to the target aldehydes was easily performed by using suitable reagents and reaction conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|