Effects of Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 and Putative Probiotic Lactobacilli on DNA Damages in the Small Intestine of Wistar Rats In Vivo
| Autor: | Marine H. Balayan, Shigeru Kamiya, Vardan V. Tsaturyan, Anahit M. Manvelyan, Astghik Z. Pepoyan, Tatevik Bezhanyan, Ruzanna Paronikyan, Stepan Tatikyan, Michael L. Chikindas, Lilit Malkhasyan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine DNA damage 030106 microbiology Microbiology law.invention 03 medical and health sciences Probiotic chemistry.chemical_compound Lactobacillus acidophilus law In vivo Intestine Small medicine Animals DNA Breaks Double-Stranded Rats Wistar Molecular Biology Strain (chemistry) Lacticaseibacillus rhamnosus Chemistry Probiotics food and beverages Molecular biology Small intestine Rats Comet assay 030104 developmental biology medicine.anatomical_structure Molecular Medicine DNA DNA Damage |
| Zdroj: | Probiotics and Antimicrobial Proteins. 11:905-909 |
| ISSN: | 1867-1314 1867-1306 |
| DOI: | 10.1007/s12602-018-9491-y |
| Popis: | Double-strand breaks in the DNA of the small intestine in male Wistar rats were studied using a neutral comet assay after 7 days of feeding with a single strain probiotic formulation Narine (Vitamax-E, Armenia), containing Lactobacillus acidophilus strain Er-2317/402 Narine, and putative probiotics L. rhamnosus Vahe and L. delbrueckii IAHAHI. Type 0 (undamaged DNA), type 1 (head diameter 13.18–17.08 μm), and type 2 (14.15-μm head diameter) damaged DNA comets were studied in control and lactobacilli-fed rats using the neutral comet assay. Lactobacilli-fed rats were shown to carry only type 0 (undamaged) DNA. Thus, the effects of probiotic Lactobacillus acidophilus strain INMIA 9602 Er 317/402 and putative probiotic lactobacilli on DNA damage in the small intestine of Wistar rats in vivo was shown, and the neutral comet assay is suggested as a potential tool for the in vivo selection of putative probiotics with DNA-protective activity. |
| Databáze: | OpenAIRE |
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