In vivo activity of ursolic and oleanolic acids during the acute phase of Trypanosoma cruzi infection
| Autor: | Míriam Paula Alonso Toldo, Daniele da Silva Ferreira, Viviane Rodrigues Esperandim, Sergio de Albuquerque, Wilson Roberto Cunha, José Clóvis do Prado Júnior, Christian Collins Kuehn, Márcio Luis Andrade e Silva |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Immunology Administration Oral Parasitemia Intestinal absorption Interferon-gamma Mice Random Allocation chemistry.chemical_compound Immune system Anti-Infective Agents Ursolic acid Oral administration parasitic diseases medicine ANTIPARASITÁRIOS (FARMACOLOGIA) Animals Chagas Disease Infusions Parenteral Oleanolic Acid Trypanosoma cruzi Oleanolic acid Mice Inbred BALB C biology Interleukin General Medicine medicine.disease biology.organism_classification Trypanocidal Agents Triterpenes Interleukin-10 Disease Models Animal Infectious Diseases chemistry Nitroimidazoles Acute Disease Melastomataceae Parasitology |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0014-4894 |
| Popis: | Reduction in the parasitemic levels of the Y strain of Trypanosoma cruzi in mice treated with oral or intraperitoneal ursolic (UA) and oleanolic (OA) acids was evaluated during the acute phase of Chagas' disease. Oral administration of UA and OA (50mg/kg/day) provided the most significant reduction in the parasitemic peak, while intraperitoneal administration of UA and OA did not significantly affect the biological activity of the Y strain of T. cruzi. Interleukin levels in mice treated by the intraperitoneal route were compared to untreated chagasic mice. Reduced γ-IFN levels and enhanced IL-10 concentrations potentially explain the exacerbated parasitemia. Our data suggests an immunosuppressive effect for UA and OA, which could interfere with host control of parasitemia. Optimal results were achieved with oral administration. This observation may be explained by the low intestinal absorption of UA and OA, could cause a reduced immune response and promote parasite control. Taken together, these data demonstrate that triterpenes could be interesting compounds to develop therapeutically for the treatment of Chagas' disease. |
| Databáze: | OpenAIRE |
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