Plasmacytoid Urothelial Carcinoma: Response to Chemotherapy and Oncologic Outcomes
| Autor: | Michael T. Schweizer, Evan Y. Yu, Leonidas Nikolaos Diamantopoulos, Jonathan L. Wright, John K. Lee, Maria S. Tretiakova, Andrew C. Hsieh, Sarah P. Psutka, Funda Vakar-Lopez, Todd Yezefski, Robert B. Montgomery, John L. Gore, Ali Raza Khaki, George R. Schade, Daniel W. Lin, Petros Grivas, Heather H. Cheng |
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| Rok vydání: | 2020 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Bladder cancer Proportional hazards model business.industry Urology Incidence (epidemiology) medicine.medical_treatment 030232 urology & nephrology medicine.disease Article Cystectomy 03 medical and health sciences 0302 clinical medicine Transitional cell carcinoma Oncology 030220 oncology & carcinogenesis medicine Stage (cooking) business Neoadjuvant therapy |
| Zdroj: | Bladder Cancer |
| ISSN: | 2352-3735 2352-3727 |
| Popis: | BACKGROUND: Plasmacytoid urothelial carcinoma is a rare bladder cancer variant with scarce data on outcomes and prognostic factors. OBJECTIVE: We report our institutional experience with this histology to determine response to neoadjuvant chemotherapy, definitive surgery and survival. METHODS: We conducted a retrospective chart review of consecutive patients with plasmacytoid, as well as conventional urothelial carcinoma (for comparison) seen in our institution (2007– 2018). Baseline characteristics, clinicopathologic and treatment data were captured. T-test, chi-squared and log-rank test was used for group comparison. Kaplan Meier method was used for estimation of overall survival and Cox regression for identification of prognostic factors. RESULTS: 64 patients with plasmacytoid and 418 with conventional urothelial histology were identified; 53% of those with plasmacytoid presented with cT3/4 stage and 67% underwent extirpative surgery. Patients with plasmacytoid histology had higher rates of pT3/4 (65% vs. 28%), nodal disease (37% vs. 16%) and positive surgical margins (23% vs. 5%) compared to urothelial group (p |
| Databáze: | OpenAIRE |
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