Associations of pineal volume, chronotype and symptom severity in adults with attention deficit hyperactivity disorder and healthy controls

Autor: Barbara Alm, Oliver Hennig, Sabrina Fenske, Ingo Noelte, Peter Kirsch, Daniela Mier, Esther Sobanski, Luisa Liebrich, Carina Sauer, Jan Malte Bumb, Michael Schredl, Franz Markus Leweke
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Comorbidity
Pineal Gland
Severity of Illness Index
Melatonin
Young Adult
03 medical and health sciences
Pineal gland
0302 clinical medicine
ddc:150
Rating scale
Surveys and Questionnaires
Internal medicine
medicine
Humans
Attention deficit hyperactivity disorder
Epithalamus
Pharmacology (medical)
Circadian rhythm
Psychiatry
Biological Psychiatry
MPRAGE
MRI
Melatonin
MEQ
Morningness
Eveningness
Psychiatric Status Rating Scales
Pharmacology
Symptom severity
Chronotype
Organ Size
medicine.disease
Magnetic Resonance Imaging
Circadian Rhythm
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
Attention Deficit Disorder with Hyperactivity
Regression Analysis
Female
Neurology (clinical)
Psychology
030217 neurology & neurosurgery
medicine.drug
Zdroj: European Neuropsychopharmacology. 26:1119-1126
ISSN: 0924-977X
DOI: 10.1016/j.euroneuro.2016.03.016
Popis: The pineal gland, as part of the human epithalamus, is the main production site of peripheral melatonin, which promotes the modulation of sleep patterns, circadian rhythms and circadian preferences (morningness vs. eveningness). The present study analyses the pineal gland volume (PGV) and its association with circadian preferences and symptom severity in adult ADHD patients compared to healthy controls. PGV was determined manually using high-resolution 3T MRI (T1-magnetization prepared rapid gradient echo) in medication free adult ADHD patients (N=74) compared to healthy controls (N=86). Moreover, the Morningness-Eveningness Questionnaire (MEQ), the ADHD Diagnostic Checklist and the Wender-Utah Rating Scale were conducted. PGV differed between both groups (patients: 59.9±33.8mm(3); healthy controls: 71.4±27.2mm(3), P=0.04). In ADHD patients, more eveningness types were revealed (patients: 29%; healthy controls: 17%; P=0.05) and sum scores of the MEQ were lower (patients: 45.8±11.5; healthy controls 67.2±10.1; P
Databáze: OpenAIRE
Externí odkaz: