Challenging Mycobacterium tuberculosis dormancy mechanisms and their immunodiagnostic potential
| Autor: | Michele Fernandes Rodrigues, Ana Márcia Menezes de Mattos, Alexandre Silva Chaves, Henrique Couto Teixeira |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Tuberculosis lcsh:QR1-502 Immunologic Tests lcsh:Microbiology lcsh:Infectious and parasitic diseases Microbiology Mycobacterium tuberculosis Immune system Bacterial Proteins Latent Tuberculosis Diagnosis medicine Humans lcsh:RC109-216 Pathogen DosR antigens Immune Evasion Medicine(all) Antigens Bacterial biology Latent tuberculosis biology.organism_classification medicine.disease DNA-Binding Proteins Infectious Diseases Regulon Infectious disease (medical specialty) Host-Pathogen Interactions Latency Immunology Dormancy Protein Kinases |
| Zdroj: | Repositório Institucional da UFJF Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF Brazilian Journal of Infectious Diseases v.19 n.6 2015 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Vol 19, Iss 6, Pp 636-642 (2015) Brazilian Journal of Infectious Diseases, Volume: 19, Issue: 6, Pages: 636-642, Published: DEC 2015 |
| ISSN: | 1413-8670 |
| DOI: | 10.1016/j.bjid.2015.08.004 |
| Popis: | Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one of the world's greatest cause of morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed to its high level of adaptation as a host pathogen. Prior to become dormant, a group of about 50 genes related to metabolic changes are transcribed by the DosR regulon, one of the most complex and important systems of host-pathogen interaction. This genetic mechanism allows the mycobacteria to persist during long time periods, establishing the so-called latent infection. Even in the presence of a competent immune response, the host cannot eliminate the pathogen, only managing to keep it surrounded by an unfavorable microenvironment for its growth. However, conditions such as immunosuppression may reestablish optimal conditions for bacterial growth, culminating in the onset of active disease. The interactions between the pathogen and its host are still not completely elucidated. Nonetheless, many studies are being carried out in order to clarify this complex relationship, thus creating new possibilities for patient approach and laboratory screening. Keywords: Tuberculosis, Latency, DosR antigens, Diagnosis |
| Databáze: | OpenAIRE |
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