Effect of combined treatment with salvage radiotherapy plus androgen suppression on quality of life in patients with recurrent prostate cancer after radical prostatectomy
| Autor: | D. Andrew Loblaw, Sarat Chander, Cyril Danjoux, Ewa Szumacher, Richard Choo, Gerard Morton, Gerrit DeBoer, Patrick Cheung, Andrew Pearce |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Diarrhea
Male Oncology Cancer Research medicine.medical_specialty Antineoplastic Agents Hormonal medicine.medical_treatment Urology Phases of clinical research Androgen suppression Quality of life Prostate Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Aged Prostatectomy Salvage Therapy Radiation business.industry Penile Erection Prostatic Neoplasms Cancer Androgen Antagonists Prostate-Specific Antigen Urination Disorders medicine.disease Radiation therapy Clinical trial Intestinal Diseases medicine.anatomical_structure Quality of Life Neoplasm Recurrence Local business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 65:78-83 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2005.11.041 |
| Popis: | To examine the effect of salvage radiotherapy (RT) plus 2-year androgen suppression (AS) on quality of life (QOL).A total of 74 patients with biopsy-proven local recurrence or PSA relapse after radical prostatectomy were treated with salvage RT plus 2-year AS, as per a phase II study. Quality of life was prospectively assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30-Item Version 3.0 with the added prostate cancer-specific module at baseline and predefined follow-up visits.Patients experienced a significant increase in bowel dysfunction (23%) by the end of RT (p0.0001). This bowel dysfunction improved after RT but remained slightly elevated (5-10%) throughout the 2-year AS period. This extent of residual bowel dysfunction would be considered of minimal clinical importance. A similar, but less pronounced, pattern of change did occur for urinary dysfunction. Erectile function showed no change during RT, but had an abrupt decline (10%) with initiation of AS that was of moderate clinical significance (p0.01). None of the other QOL domains demonstrated a persistent, significant change from baseline that would be considered of major clinical significance.The combined treatment with salvage RT plus 2-year AS had relatively minor long-term effects on QOL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|