Rationale and design of a randomized trial on the effectiveness of aerobic interval training in patients with coronary artery disease
| Autor: | Nadine Possemiers, Bharati Shivalkar, Emeline M. Van Craenenbroeck, Paul Beckers, Dirk Schepers, Véronique Cornelissen, Vicky Y. Hoymans, Nele Pattyn, Viviane M. Conraads, Catherine De Maeyer, Johan Denollet, Kaatje Goetschalckx, Luc Vanhees, Geert Frederix, Ellen Coeckelberghs |
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| Přispěvatelé: | Medical and Clinical Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Coronary Artery Disease Interval training law.invention Coronary artery disease Randomized controlled trial law Internal medicine Heart rate medicine Clinical endpoint Secondary Prevention Humans Longitudinal Studies Prospective Studies Exercise Ejection fraction Exercise Tolerance business.industry Stroke Volume medicine.disease Continuous training Treatment Outcome Exercise intensity Cardiology Physical therapy Human medicine Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | International journal of cardiology International Journal of Cardiology, 168(4), 3532-3536. Elsevier Ireland Ltd |
| ISSN: | 0167-5273 |
| DOI: | 10.1016/j.ijcard.2013.05.007 |
| Popis: | Background: Exercise-based cardiac rehabilitation is considered an important adjunct treatment and secondary prevention measure in patients with coronary artery disease (CAD). However, the issues of training modality and exercise intensity for CAD patients remain controversial.Objective: Main aim of the present study is to test the hypothesis that aerobic interval training (AIT) yields a larger gain in peak aerobic capacity (peakVO2) compared to a similar training programme of moderate continuous training (MCT) in CAD patients.Study design: In this multicentre study stable CAD patients with left ventricular ejection fraction>40% will be randomized after recent myocardial infarction or revascularization (PCI or CABG) to a supervised 12-week programme of three weekly sessions of either AIT (85-90% of peak oxygen uptake [peakVO2], 90-95% of peak heart rate) or MCT (60-70% of peakVO2, 65-75% of peak heart rate). The primary endpoint of the study is the change of peakVO2 after 12 weeks training. Secondary endpoints include safety, changes in peripheral endothelial vascular function, the evolution of traditional cardiovascular risk factors, quality of life and the number and function of circulating endothelial progenitor cells as well as endothelial microparticles. Possible differences in terms of long-term adherence to prescribed exercise regimens will be assessed by regular physical activity questionnaires, accelerometry and reassessment of peakVO2 12 months after randomization. A total number of 200 patients will be randomized in a 1:1 manner (significance level of 0.05 and statistical power of 0.90). Enrolment started December 2010; last enrolment is expected for February 2013.Keywords:Exercise intensity, Exercise training, Coronary artery disease, Secondary prevention, Cardiac rehabilitation |
| Databáze: | OpenAIRE |
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