Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother–Infant Dyads as Analyzed at Time of Delivery
| Autor: | Ana Yuil-Valdes, Arzu Ulu, Ann Anderson-Berry, Sathish Kumar Natarajan, Maranda Thompson, Kristina Harris Jackson, Tara M. Nordgren, Maheswari Mukherjee, Melissa Thoene, Vanessa Woodard, Corrine Hanson, Matthew Van Ormer |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine maternal-fetal health intrauterine transfer Umbilical cord Fetal Development chemistry.chemical_compound 0302 clinical medicine Pregnancy chemistry.chemical_classification Arachidonic Acid Nutrition and Dietetics omega-3 fatty acids Fatty Acids food and beverages Fetal Blood Eicosapentaenoic acid medicine.anatomical_structure Eicosapentaenoic Acid embryonic structures Fatty Acids Unsaturated Gestation Female Arachidonic acid lipids (amino acids peptides and proteins) lcsh:Nutrition. Foods and food supply Polyunsaturated fatty acid medicine.medical_specialty placenta lcsh:TX341-641 Article Linoleic Acid 03 medical and health sciences Fetus Placenta Internal medicine Fatty Acids Omega-3 medicine Humans 030109 nutrition & dietetics business.industry Infant Fatty acid eye diseases Cross-Sectional Studies Endocrinology chemistry sense organs business 030217 neurology & neurosurgery PUFA Food Science |
| Zdroj: | Nutrients Volume 13 Issue 3 Nutrients, Vol 13, Iss 996, p 996 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13030996 |
| Popis: | Polyunsaturated fatty acids (PUFAs) are essential for fetal development, and intrauterine transfer is the only supply of PUFAs to the fetus. The prevailing theory of gestational nutrient transfer is that certain nutrients (including PUFAs) may have prioritized transport across the placenta. Numerous studies have identified correlations between maternal and infant fatty acid concentrations however, little is known about what role maternal PUFA status may play in differential intrauterine nutrient transfer. Twenty mother–infant dyads were enrolled at delivery for collection of maternal and umbilical cord blood, and placental tissue samples. Plasma concentrations of PUFAs were assessed using gas chromatography (GC-FID). Intrauterine transfer percentages for each fatty acid were calculated as follows: ((cord blood fatty acid level/maternal blood fatty acid level) x 100). Kruskal–Wallis tests were used to compare transfer percentages between maternal fatty acid tertile groups. A p-value < 0.05 was considered significant. There were statistically significant differences in intrauterine transfer percentages of arachidonic acid (AA) (64% vs. 65% vs. 45%, p = 0.02), eicosapentaenoic acid (EPA) (41% vs. 19% vs. 17%, p = 0.03), and total fatty acids (TFA) (27% vs. 26% vs. 20%, p = 0.05) between maternal plasma fatty acid tertiles. Intrauterine transfer percentages of AA, EPA, and TFA were highest in the lowest tertile of respective maternal fatty acid concentration. These findings may indicate that fatty acid transfer to the fetus is prioritized during gestation even during periods of maternal nutritional inadequacy. |
| Databáze: | OpenAIRE |
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