High Prevalence and Resistance Patterns of Community-Associated Methicillin-Resistant Staphylococcus Aureus in the Pomoravlje Region, Serbia
| Autor: | Srdjan Lazic, Ljiljana Petrovic Jeremic, Ivana Cirkovic, Zorica Lepsanovic |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Methicillin-Resistant Staphylococcus aureus Pediatrics medicine.medical_specialty medicine.drug_class 030106 microbiology Antibiotics Microbial Sensitivity Tests medicine.disease_cause Staphylococcal infections 03 medical and health sciences Methicillin Young Adult Antibiotic resistance Internal medicine Genotype medicine Humans Pathogen General Immunology and Microbiology Resistance pattern business.industry SCCmec General Medicine biochemical phenomena metabolism and nutrition Staphylococcal Infections bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus 3. Good health Anti-Bacterial Agents Community-Acquired Infections Female Methicillin Resistance business Serbia |
| Zdroj: | Acta microbiologica et immunologica Hungarica. 63(1) |
| ISSN: | 1217-8950 |
| Popis: | With a view to estimating the prevalence and resistance patterns of CA-MRSA in one region of Serbia, we performed an analysis of MRSA isolates from healthy people and hospitalised patients. The detection of CA-MRSA was carried out by SCCmec typing. In MRSA isolates from hospitalised patients SCCmec types IV and V were found in 76% of the strains. Similar percentage (80%) of CA-MRSA genotypes was present in healthy people. SCCmec type V harbouring MRSA was the most successful clone. Higher prevalence of type V in hospitalised patients to that in healthy people (70% vs 54%) may indicate nosocomial transmissions in at least some hospital units. All MRSA strains from hospitalised patients were resistant to one or more non-β-lactam antibiotics while 52% were multi-resistant. In isolates from healthy people, 16% were sensitive to all non-β-lactam antibiotics and 40% were multi-resistant. Similar percentage of multi-resistant CA- and HA-genotypes occurred in a particular environment (53% vs 50% in hospitalised patients, and 37.5% vs 37.5% in healthy people) indicating selective pressure of antibiotics as a leading force conferring antibiotic resistance. High prevalence of CA-MRSA and high resistance rate both in hospitals and the community suggest that this pathogen has been present in the Pomoravlje Region, central Serbia for years. |
| Databáze: | OpenAIRE |
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