Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells
| Autor: | Pietro Ghezzi, A. Mantovani, Charles A. Dinarello, M. Bianchi, Annalaura Erroi |
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| Rok vydání: | 1990 |
| Předmět: |
Lipopolysaccharides
Allergy Immunology Ambroxol Pharmacology Toxicology Peripheral blood mononuclear cell Tumor necrosis factor production TNF production Escherichia coli medicine Humans Pharmacology (medical) RNA Messenger Cells Cultured Tumor Necrosis Factor-alpha Chemistry Interleukin medicine.disease Toxicity Leukocytes Mononuclear Tumor necrosis factor alpha Interleukin-1 medicine.drug |
| Zdroj: | Agents and Actions. 31:275-279 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01997619 |
| Popis: | We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 microgram ml, without any apparent toxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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