Pulmonary Fibrosis in Response to Environmental Cues and Molecular Targets Involved in Its Pathogenesis
| Autor: | Aya Ohnuma, Haruka Horiuchi, Takanori Harada, Toshinori Yoshida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
TGF-β
regulatory T cell nylon flock business.industry Regulatory T cell chemokine receptor Disease Review Toxicology Bioinformatics medicine.disease Bone morphogenetic protein beryllium Pathology and Forensic Medicine Genetically modified organism Pathogenesis Chemokine receptor medicine.anatomical_structure Immunology Pulmonary fibrosis medicine Molecular targets DDAC business |
| Zdroj: | Journal of Toxicologic Pathology |
| ISSN: | 1881-915X 0914-9198 |
| Popis: | Chronic lung injury resulting from a variety of different causes is frequently associated with the develop ment of pulmonary fibrosis in humans. Although the etiology of pulmonary fibrosis is generally unknown, several sources of evidence support the hypothesis that a number of environmental and occupational agents play an etiologic role in the pathogenesis of this disease. The agents discussed in this review include beryllium, nylon flock, textile printing aerosols, polyvinyl chloride and didecyldimethylammonium chloride. The authors also describe a variety of animal models, including genetically modified mice, in order to investigate the molecular mechanism of pulmonary fibrosis, focusing on chemokine receptors, regulatory T cells and transforming growth factor-β and bone morphogenetic protein signaling. Overall, we propose the concept of toxicological pulmonary fibrosis as a lung disease induced in response to environmental cues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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