Serum β-Klotho concentrations are increased in women with polycystic ovary syndrome
| Autor: | Jolanta Fryczak, Agnieszka Siejka, Sylwia Bednarska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Infertility medicine.medical_specialty FGF21 Adolescent media_common.quotation_subject Immunology Reference range urologic and male genital diseases Biochemistry Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy Klotho Proteins Molecular Biology Klotho Menstrual cycle media_common business.industry Incidence (epidemiology) Membrane Proteins FGF19 Hematology medicine.disease Polycystic ovary female genital diseases and pregnancy complications Fibroblast Growth Factors 030104 developmental biology Endocrinology 030220 oncology & carcinogenesis Female business Polycystic Ovary Syndrome |
| Zdroj: | Cytokine. 134:155188 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2020.155188 |
| Popis: | Polycystic ovary syndrome (PCOS) is a significant cause of menstrual disorders and infertility in women. The aim of this study was to evaluate the levels of Klotho expression in women with polycystic ovary syndrome. The study involved 67 patients with PCOS, as well as 18 controls. Serum levels of FGF19, FGF21 and β-Klotho were measured by ELISA technique. The blood samples were obtained between days 2 and 7 of menstrual cycle. The concentrations of β-Klotho, FGF19 and FGF21 were significantly increased in patients with PCOS; and appear to be statistically significant predictors of PCOS incidence. FGF19 (p = 0.031, OR = 1.01), exact β-Klotho levels (p = 0.022, OR = 1.01) and β-Klotho beyond the reference range (p = 0.008, OR = 4.66) were the most strongly correlated with the diagnosis of PCOS. In conclusion, FGF19, FGF21 and β-Klotho are increased in PCOS, and elevated β-Klotho concentration may become an useful diagnostic test for this disease. However, additional studies are required to further substantiate this observation. |
| Databáze: | OpenAIRE |
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