Loss of Cardio-Protective Effects at the CDH13 Locus Due to Gene-Sleep Interaction: The BCAMS Study
| Autor: | Ming Li, Shan Gao, Ge Li, Yonghui Wang, Lanwen Han, Struan F.A. Grant, Lujiao Li, Dan Feng, Junling Fu, Mingyao Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty lcsh:Medicine Genome-wide association study Type 2 diabetes 030204 cardiovascular system & hematology Left ventricular hypertrophy General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Allele Genetic association lcsh:R5-920 Adiponectin business.industry lcsh:R General Medicine medicine.disease 030104 developmental biology Cardiology Metabolic syndrome business lcsh:Medicine (General) Body mass index |
| Zdroj: | EBioMedicine, Vol 32, Iss, Pp 164-171 (2018) |
| ISSN: | 2352-3964 |
| Popis: | Left ventricular mass index (LVMI) provides a metric for cardiovascular disease risk. We aimed to assess the association of adiponectin-related genetic variants resulting from GWAS in East Asians (loci in/near CDH13, ADIPOQ, WDR11FGF, CMIP and PEPD) with LVMI, and to examine whether sleep duration modified these genetic associations in youth. The 559 subjects aged 15–28 years were recruited from the Beijing Child and Adolescent Metabolic Syndrome study. Among the six loci, CDH13 rs4783244 was significantly correlated with adiponectin levels (p = 8.07 × 10−7). The adiponectin-rising allele in rs4783244 locus was significantly associated with decreased LVMI (p = 6.99 × 10−4) after adjusting for classical cardiovascular risk factors, and further for adiponectin levels, while no significant association was found between the other loci and LVMI. Moreover, we observed a significant interaction effect between rs4783244 and sleep duration (p = .005) for LVMI; the genetic association was more evident in long sleep duration while lost in short sleep duration. Similar interaction was found in the subgroup analysis using longitudinal data (p = .025 for interaction). In this young Chinese population, CDH13 rs4783244 represents a key locus for cardiac structure, and confers stronger cardio-protection in longer sleep duration when contrasted with short sleep duration. Keywords: Adiponectin-associated locus, CDH13, Adiponectin, Left ventricular mass index, Sleep time |
| Databáze: | OpenAIRE |
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