Persistent organic pollutants in pregnant women potentially affect child development and thyroid hormone status
| Autor: | Olle Söder, Hannu Kiviranta, Wieland Kiess, Anna Krönke, Anne Jurkutat, Matthias Nüchter, Antje Körner, Anja Hilbert, Maike Schlingmann, Carl G. Bornehag, Tanja Poulain, Mandy Vogel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
business.industry Birth weight Thyroid Physiology Reproduktionsmedicin och gynekologi Public Health Global Health Social Medicine and Epidemiology 010501 environmental sciences 01 natural sciences Child development Prenatal development 03 medical and health sciences Folkhälsovetenskap global hälsa socialmedicin och epidemiologi 030104 developmental biology medicine.anatomical_structure Obstetrics Gynecology and Reproductive Medicine Pediatrics Perinatology and Child Health Cohort Endocrine system Medicine medicine.symptom business Weight gain 0105 earth and related environmental sciences Hormone |
| Popis: | Background Potentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed. Methods Working with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child. Results Maternal p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p′-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p′-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p′-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child. Conclusions These results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child. Impact Pregnant women in a German cohort display a substantial accumulation of POPs. Body mass index and age influence maternal serum POP levels. Maternal POP levels show correlations with the child’s length at birth and weight gain, and FT3 levels in the mother and child. Our data provide additional evidence for the potentially harmful influence of POPs. Our data indicate that POPs influence pre- and postnatal development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|