Risk factors for respiratory syncytial virus bronchiolitis hospitalizations in children with chronic diseases
| Autor: | Dario Prais, Ophir Bar-On, Hagit Levine, Meir Mei-Zahav, Hannah Blau, Guy Steuer, Yulia Gendler, Einat Shmueli, Huda Mussaffi, Patrick Stafler, Ori Goldberg |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Palivizumab Pediatrics medicine.medical_specialty Respiratory Syncytial Virus Infections Antiviral Agents Virus 03 medical and health sciences 0302 clinical medicine Risk Factors Interquartile range 030225 pediatrics Humans Medicine Respiratory system Child Retrospective Studies Pediatric intensive care unit business.industry Infant Retrospective cohort study medicine.disease Respiratory Syncytial Viruses Hospitalization medicine.anatomical_structure 030228 respiratory system Bronchiolitis Chronic Disease Pediatrics Perinatology and Child Health business Respiratory tract medicine.drug |
| Zdroj: | Pediatric Pulmonology. 56:2204-2211 |
| ISSN: | 1099-0496 8755-6863 |
| DOI: | 10.1002/ppul.25435 |
| Popis: | BACKGROUND Respiratory syncytial virus (RSV) bronchiolitis is the most common lower respiratory tract disorder causing hospitalization in infants. Due to decreased hospitalization rates of premature infants following Palivizumab immune prophylaxis, the proportion of infants with chronic diseases not eligible for Palivizumab has increased. AIM To characterize infants hospitalized during 2014-2018 with RSV bronchiolitis, to compare between those with and without chronic conditions, and to identify risk factors for severe disease. METHODS This retrospective study analyzed demographic and clinical data of patients younger than 2 years admitted with bronchiolitis during four consecutive RSV seasons. RESULTS Of 1124 hospitalizations due to RSV bronchiolitis, 244 (22%) were in infants with chronic diseases. Although 20/1124 qualified for RSV prophylaxis, only eight received immune prophylaxis. Compared to otherwise healthy infants, children with chronic diseases had longer hospitalizations, median 4.8 days (interquartile range [IQR]: 3.4-8.3) versus 3.7 days (IQR: 2.7-5.1), p |
| Databáze: | OpenAIRE |
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