Comparing cardiovascular risk factors in older persons with mild cognitive impairment and lifetime history of major depressive disorder
| Autor: | Linda Mah, Christopher R. Bowie, Meryl A. Butters, Angela C. Golas, Damien Gallagher, David G. Munoz, Ines Kortebi, Benoit H. Mulsant, Tom A. Schweizer, Bruce G. Pollock, Corinne E. Fischer, Wael K Karameh, Tarek K. Rajji, Krista L. Lanctôt, Nathan Herrmann, Sanjeev Kumar, Alastair J. Flint |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neuropsychological Tests Transcranial Direct Current Stimulation Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine mental disorders medicine Dementia Humans Cognitive Dysfunction Cognitive decline Aged Aged 80 and over Depressive Disorder Major 030214 geriatrics medicine.diagnostic_test business.industry Neuropsychology Neuropsychological test medicine.disease Psychiatry and Mental health Clinical Psychology Cognitive remediation therapy Cardiovascular Diseases Heart Disease Risk Factors Cohort Hypertension Major depressive disorder Geriatrics and Gerontology business Gerontology 030217 neurology & neurosurgery Cohort study |
| Zdroj: | International psychogeriatrics. 34(6) |
| ISSN: | 1741-203X 1041-6102 |
| Popis: | Objectives:To compare the prevalence of select cardiovascular risk factors (CVRFs) in patients with mild cognitive impairment (MCI) versus lifetime history of major depression disorder (MDD) and a normal comparison group using baseline data from the Prevention of Alzheimer’s Dementia with Cognitive Remediation plus Transcranial Direct Current Stimulation (PACt-MD) study.Design:Baseline data from a multi-centered intervention study of older adults with MCI, history of MDD, or combined MCI and history of MDD (PACt-MD) were analyzed.Setting:Community-based multi-centered study based in Toronto across 5 academic sites.Participants:Older adults with MCI, history of MDD, or combined MCI and history of MDD and healthy controls.Measurements:We examined the baseline distribution of smoking, hypertension and diabetes in three groups of participants aged 60+ years in the PACt-MD cohort study: MCI (n = 278), MDD (n = 95), and healthy older controls (n = 81). Generalized linear models were fitted to study the effect of CVRFs on MCI and MDD as well as neuropsychological composite scores.Results:A higher odds of hypertension among the MCI cohort compared to healthy controls (p < .05) was noted in unadjusted analysis. Statistical significance level was lost on adjusting for age, sex and education (p > .05). A history of hypertension was associated with lower performance in composite executive function (p < .05) and overall composite neuropsychological test score (p < .05) among a pooled cohort with MCI or MDD.Conclusions:This study reinforces the importance of treating modifiable CVRFs, specifically hypertension, as a means of mitigating cognitive decline in patients with at-risk cognitive conditions. |
| Databáze: | OpenAIRE |
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