Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function
| Autor: | Alberto Righetti, Jean-Paul Vallée, Pascal Chatelain, Dominique Didier, François Lazeyras, Larry Kasuboski, Nigel Richard Howarth |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Gadolinium DTPA
Male Cardiac function curve Calibration curve Gadolinium Contrast Media chemistry.chemical_element Perfusion scanning Bolus (medicine) In vivo Coronary Circulation Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging medicine.diagnostic_test Phantoms Imaging business.industry Models Cardiovascular Heart Magnetic resonance imaging Middle Aged Magnetic Resonance Imaging chemistry Calibration cardiovascular system Female business Nuclear medicine Perfusion |
| Zdroj: | Journal of Magnetic Resonance Imaging. 9:197-203 |
| ISSN: | 1522-2586 1053-1807 |
| DOI: | 10.1002/(sici)1522-2586(199902)9:2<197::aid-jmri7>3.0.co;2-x |
| Popis: | The present study reports on a new calibration of the magnetic resonance imaging (MRI) signal intensity of a fast gradient-echo sequence used for in vivo myocardial perfusion quantification in patients. The signal from a FAST sequence preceded by a arrhythmia-insensitive magnetization preparation was calibrated in vitro using tubes filled with various gadolinium (Gd) solutions. Single short-axis views of the heart were obtained in patients (n = 10) with normal cardiac function. Myocardial and blood signal intensity were converted to concentration of Gd according to the in vitro calibration curve and fitted by a one-compartment model. K1 [first-order transfer constant from the blood to the myocardium for the gadolinium-diethylenetriamine-pentaacetic acid (Gd-DTPA)] and Vd (distribution volume of Gd-DTPA in myocardium) obtained from the fit of the MRI-derived perfusion curves were 0.72+/-0.22 (mL/min/g) and 15.3+/-5.22%. These results were in agreement with previous observations on animals and demonstrated that a reliable measurement of myocardial perfusion can be obtained by MRI in patients with an in vitro calibration procedure. |
| Databáze: | OpenAIRE |
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