Effects of adolescent administration of fluoxetine on novel object recognition memory, anxiety-like behaviors, and hippocampal brain-derived neurotrophic factor level
| Autor: | Raziyeh Dehghany, Hakimeh Saadati, Omid Adak, Farshid Sadegzadeh, Nona Sakhaie |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty animal structures Serotonin reuptake inhibitor Hippocampal formation Anxiety Serotonergic 030226 pharmacology & pharmacy Hippocampus General Biochemistry Genetics and Molecular Biology Open field 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Internal medicine Fluoxetine medicine Animals General Pharmacology Toxicology and Pharmaceutics Brain-derived neurotrophic factor Memory Disorders business.industry Brain-Derived Neurotrophic Factor Cognition Recognition Psychology General Medicine Rats 030104 developmental biology Endocrinology Female business Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Life sciences. 260 |
| ISSN: | 1879-0631 |
| Popis: | Aims Fluoxetine (FLX) is a common selective serotonin reuptake inhibitor, which is used in adolescents with psychiatric disorders. Controversial results have been obtained in different studies about the effects of FLX on cognitive functions. The present study was designed to examine the effects of chronic FLX exposure during adolescence on cognitive function, anxiety-like behaviors, and hippocampal brain-derived neurotrophic factor (BDNF) mRNA expression among adult male and female rats. Main methods The sex-dependent effects of FLX chronic administration during adolescence (5 mg/kg/day, gavage) on short-term novel object recognition memory (NORM), anxiety-like behaviors, and BDNF mRNA expression in the hippocampus were examined. NORM and anxiety-like behaviors were assessed by novel object recognition, open field, and elevated plus-maze (EPM) tests, respectively. The expression of BDNF mRNA was also evaluated by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Key findings The present findings revealed the dysfunction of short-term NORM among the adolescent male and female rats exposed to FLX, while the mRNA expression of BDNF was significantly higher among the males. Moreover, adolescent FLX administration had different effects on the anxiety-like behaviors of the male and female rats. Adolescent FLX treatment also decreased the body weight of the male animals. Significance In conclusion, adolescent FLX treatment impairs cognitive functions in both sexes and increases BDNF mRNA expression in the hippocampus of the male animals. FLX administration during adolescence has sex-dependent effects on anxiety-like behaviors. These findings indicate that the impairment of cognitive functions can occur following the adolescent manipulation of the serotonergic system. Therefore, the side effects of chronic FLX administration during adolescence should be more considered. |
| Databáze: | OpenAIRE |
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