Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
| Autor: | Masood Sepehrimanesh, Negar Azarpira, Azadeh Sayarifard, Moosa Salehi, Fatemeh Hosseinzadeh, Nader Tanideh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences grapeseed oil medicine.disease_cause Gastroenterology sesame oil 0403 veterinary science 03 medical and health sciences Acetic acid chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine oxidative stress 030212 general & internal medicine lcsh:RC799-869 ulcerative colitis Traditional medicine business.industry 04 agricultural and veterinary sciences General Medicine medicine.disease Ulcerative colitis Kowsar chemistry histopathology Medicine lcsh:Diseases of the digestive system. Gastroenterology Sesame oil Histopathology business Oxidative stress |
| Zdroj: | Iranian Journal of Colorectal Research, Vol 4, Iss 2 (2016) Annals of Colorectal Research, Vol 4, Iss 2 (2016) |
| ISSN: | 2783-2430 |
| Popis: | Background Ulcerative colitis (UC) is a multi-factorial disease with unknown etiology and has many clinical manifestations. Objectives The current study aimed to evaluate the effects of sesame oil (SO) and grapeseed oil (GSO) on acetic acid-induced UC in rats. Materials and Methods Eighty male rats were divided into eight groups as health control (HC1), received normal saline; HC2, received SO; HC3, received GSO; negative control (NC), UC and normal saline; positive control (PC), UC and mesalamine; SO, UC and SO; GSO, UC and GSO, and SO + GSO. The daily weight changes, serum levels of oxidative stress markers and lipid profile plus colon macroscopic and microscopic histological changes were measured at the end of the seventh day. Results Significant differences were detected between HC1 and PC on the 3rd (P = 0.002), 4th (0.013) and 6th days (0.014) and between HC1 and NC on the 4th day (0.027) in weight of rats. Use of GSO alone or in combination with SO decreased the extent of the changes both in macroscopic and microscopic indices and also at the inflammation level. The most significant decrease in the MDA level and the most obvious increase in the TAC belonged to the GSO group in comparison to the NC group. The lowest cholesterol (51.43 ± 5.62 mg/dL) and HDL levels (29.29 ± 6.24 mg/dL) were detected in response to SO consumption in comparison to NC group (P = 0.030 and P = 0.257, respectively). Conclusions GSO in combination with SO may be considered as the treatment of choice for UC based on antioxidant and histopathological evaluations. |
| Databáze: | OpenAIRE |
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