A comparison study of outcome measures for epidermolysis bullosa: Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) and the Instrument for Scoring Clinical Outcomes of Research for Epidermolysis Bullosa (iscorEB)Capsule Summary
| Autor: | John C Su, Johannes S. Kern, Clare L. Rogers, Dedee F. Murrell, Benjamin S. Daniel, Matthew J. Gibson, Grant Feng, Susan J. Robertson, Oliver G. C. Murrell, Linda K. Martin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
DDEB dominant dystrophic epidermolysis bullosa Intraclass correlation EBS epidermolysis bullosa simplex Junctional epidermolysis bullosa (medicine) JEB junctional epidermolysis bullosa Epidermolysis bullosa simplex RDEB recessive dystrophic epidermolysis bullosa blistering skin disease BMD bone mineral densitometry lcsh:Dermatology Medicine epidermolysis bullosa Instrument for Scoring Clinical Outcomes of Research for Epidermolysis Bullosa ICC intraclass correlation coefficient outcome measure business.industry iscorEB Instrument for Scoring Clinical Outcomes of Research for Epidermolysis Bullosa EB epidermolysis bullosa Discriminant validity Intra-rater reliability lcsh:RL1-803 EBDASI Epidermolysis Bullosa Disease Activity and Scarring Index medicine.disease QoL quality of life Dermatology dermatology Inter-rater reliability QOLEB Quality of Life in Epidermolysis Bullosa score Convergent validity Epidermolysis Bullosa Disease Activity and Scarring Index Original Article Epidermolysis bullosa business BEBS Birmingham Epidermolysis Bullosa Severity Score |
| Zdroj: | JAAD International, Vol 2, Iss, Pp 134-152 (2021) JAAD International |
| ISSN: | 2666-3287 |
| Popis: | Background The success of clinical trials in Epidermolysis Bullosa (EB) is dependent upon the availability of a valid and reliable scoring tool that can accurately assess and monitor disease severity. The Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) and Instrument for Scoring Clinical Outcomes of Research for Epidermolysis Bullosa (iscorEB) were independently developed and validated against the Birmingham Epidermolysis Bullosa Severity Score but have never been directly compared. Objective To compare the reliability, convergent validity, and discriminant validity of the EBDASI and iscorEB scoring tools. Methods An observational cohort study was conducted in 15 patients with EB. Each patient was evaluated using the EBDASI and iscorEB-clinician scoring tools by 6 dermatologists with expertise in EB. Quality of life was assessed using the iscorEB-patient and Quality of Life in EB measures. Results The intraclass correlation coefficients for interrater reliability were 0.942 for the EBDASI and 0.852 for the iscorEB-clinician. The intraclass correlation coefficients for intrarater reliability was 0.99 for both scores. The two tools demonstrated strong convergent validity with each other. Conclusion Both scoring tools demonstrate excellent reliability. The EBDASI appears to better discriminate between EB types and disease severities. |
| Databáze: | OpenAIRE |
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