Dynamic contrast-enhanced computed tomography in the treatment evaluation of patients with colorectal liver metastases treated with ablation: a feasibility study
| Autor: | Andersen, Iben R, Olesen, Rene, Boysen, Anders K, Jensen, Lars H, Mortensen, Frank V, Nielsen, Dennis T, Rasmussen, Finn |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_treatment Contrast Media interventional THERMAL ABLATION 030218 nuclear medicine & medical imaging 0302 clinical medicine outcome analysis Liver Neoplasms/diagnostic imaging PERFUSION Radiographic Image Enhancement/methods Prospective Studies Prospective cohort study Four-Dimensional Computed Tomography/methods HEPATIC-TUMORS ablation procedures Aged 80 and over Radiological and Ultrasound Technology Liver Neoplasms Dynamic Contrast Enhanced Computed Tomography General Medicine Liver/diagnostic imaging Middle Aged Ablation CANCER Radiographic Image Enhancement Treatment Outcome Liver 030220 oncology & carcinogenesis Catheter Ablation Female Radiology Colorectal Neoplasms CT Adult medicine.medical_specialty Catheter ablation PERCUTANEOUS RADIOFREQUENCY ABLATION 03 medical and health sciences medicine Recurrent disease Humans Radiology Nuclear Medicine and imaging Four-Dimensional Computed Tomography metastases RECURRENCE Aged Colorectal Neoplasms/pathology business.industry segmentation Quantitative CT Tumor tissue Treatment evaluation Feasibility Studies business Insufficient Heating |
| Zdroj: | Andersen, I R, Thorup, K, Jepsen, B N, Mortensen, F V, Nielsen, D T & Rasmussen, F 2019, ' Dynamic contrast-enhanced computed tomography in the treatment evaluation of patients with colorectal liver metastases treated with ablation: a feasibility study ', Acta Radiologica, vol. 60, no. 8, pp. 936-945 . https://doi.org/10.1177/0284185118806661 Andersen, I R, Olesen, R, Boysen, A K, Jensen, L H, Mortensen, F V, Nielsen, D T & Rasmussen, F 2018, ' Dynamic contrast-enhanced computed tomography in the treatment evaluation of patients with colorectal liver metastases treated with ablation : a feasibility study ' Acta Radiologica-Series Diagnosis . https://doi.org/10.1177/0284185118806661 |
| ISSN: | 1600-0455 |
| DOI: | 10.1177/0284185118806661 |
| Popis: | Background A major concern following ablation treatment is the risk of insufficient heating leaving vital tumor tissue at the treatment site, leading to recurrent disease and reduced survival. Dynamic contrast-enhanced computed tomography (DCE-CT) has the potential to evaluate the treatment site in an objective and standardized manner and provide a marker of recurrent disease. Purpose To evaluate the feasibility of measuring changes in the dynamic parameters of the treatment site following ablation of colorectal liver metastases, assessed by DCE-CT using a novel evaluation method, applying a circumferential semi-automated attenuation-restricted volume of interest (VOI). Material and Methods Forty-three treatment sites following ablation in 39 patients with colorectal liver metastases were evaluated using DCE-CT. A total of 159 DCE-CT scans were analyzed using the circumferential semi-automatized VOI. Results We found no significant differences in the dynamic parameters over time between a group of patients with recurrent disease and a group without. No consistent associations between time to recurrence and the dynamic histogram parameters were identified. Conclusion In this exploratory feasibility study, we were not able to differentiate between the two groups (recurrence/no recurrence) using the dynamic parameters derived from the standardized circumferential VOI. In time, the method may have potential to evaluate the treatment site following ablation in an objective and standardized manner. Currently, the method needs further refinement before clinical implementation. |
| Databáze: | OpenAIRE |
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