Repeat-Modulated Population Genetic Effects in Fungal Proteins
| Autor: | David A. Liberles, F. N. Braun |
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| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular Nonsynonymous substitution Protein Folding Population medicine.disease_cause Fungal Proteins Gene Duplication Gene duplication Genetics medicine Point Mutation Gene Silencing Amino Acids Codon education Molecular Biology Gene Ecology Evolution Behavior and Systematics education.field_of_study Mutation Fungal protein Models Genetic biology Fungi Crassa biology.organism_classification Stop codon Genetics Population |
| Zdroj: | Journal of Molecular Evolution. 59 |
| ISSN: | 1432-1432 0022-2844 |
| DOI: | 10.1007/s00239-004-2608-9 |
| Popis: | A number of fungal lineages, notably N. crassa, have evolved a novel mechanism of processing genomic duplication events known as repeat-induced point (RIP) mutation. This mechanism appears, on the one hand, to act as a conservative genomic safeguard, by introducing stop codons into duplicated nucleotide sequences, thereby preempting consequences such as dosage effects. However, it also typically performs further nonsynonymous (i.e., amino acid-changing) nucleotide substitutions, the significance of which is unclear. We explore here the possibility that RIP-mutated genes which evade silencing may have some microevolutionary impact on functional sequences. Our approach focuses on structurally important hydrophobic/polar (HP) amino-acid substitutions effected by RIP. We exploit a simple generic protein folding model to predict the associated emergence of increased protein-structural stability and variance within a large population. |
| Databáze: | OpenAIRE |
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