Principles and application of LIMS in mouse clinics
| Autor: | Juan Gallegos, Kimio Kobayashi, Mark Griffiths, Tomohiro Suzuki, Navis Pretheeba Raj, Helmut Fuchs, Holger Maier, Sophie Leblanc, Martin Hrabě de Angelis, David S. Richardson, Rafael Alcantara, Laurent Vasseur, S. Holroyd, Arthur Evans, Shigeharu Wakana, Neha Agrawal, Christine Schütt, Valerie Gailus-Durner, Christian Kipp, Elida Schneltzer, Dave Clary, Ralph Steinkamp, David Melvin, Nobuhiko Tanaka, Christoph Lengger, Hiroshi Masuya, Alison Walling, Philipp Gormanns, David Gannon, Anja Hurt |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Decision support system
Biomedical Research animal structures 040301 veterinary sciences Data management Automatic identification and data capture Biology Bioinformatics Article Domain (software engineering) 0403 veterinary science 03 medical and health sciences Mice Genetics Animals 030304 developmental biology 0303 health sciences business.industry 04 agricultural and veterinary sciences Schedule (project management) Business process modeling Management information systems Major conclusion Software engineering business Clinical Laboratory Information Systems Software |
| Zdroj: | Mamm. Genome 26, 467-481 (2015) Europe PubMed Central Mammalian Genome |
| Popis: | Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to a standardised schedule. All these efforts are typically organised in overlapping projects, running in parallel. In terms of logistics, data capture, data analysis, result visualisation and reporting, new challenges have emerged from such projects. These challenges could hardly be met with traditional methods such as pen & paper colony management, spreadsheet-based data management and manual data analysis. Hence, different Laboratory Information Management Systems (LIMS) have been developed in mouse clinics to facilitate or even enable mouse and data management in the described order of magnitude. This review shows that general principles of LIMS can be empirically deduced from LIMS used by different mouse clinics, although these have evolved differently. Supported by LIMS descriptions and lessons learned from seven mouse clinics, this review also shows that the unique LIMS environment in a particular facility strongly influences strategic LIMS decisions and LIMS development. As a major conclusion, this review states that there is no universal LIMS for the mouse research domain that fits all requirements. Still, empirically deduced general LIMS principles can serve as a master decision support template, which is provided as a hands-on tool for mouse research facilities looking for a LIMS. Electronic supplementary material The online version of this article (doi:10.1007/s00335-015-9586-7) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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