Clinical and electrophysiological profiles in early recognition of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome
| Autor: | Qin Wang, Peng Liu, Li-Li Ji, Shuai Wu, Guo-Dong Feng, Xin Wang, Ji-Hong Dong, Li-Shao Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Chronic inflammatory demyelinating polyradiculoneuropathy medicine.medical_specialty lcsh:Medicine Chronic inflammatory demyelinating polyneuropathy Endocrinopathy Gastroenterology Organomegaly 03 medical and health sciences Polyneuropathies Terminal latency index 0302 clinical medicine Internal medicine Polyneuropathy Medicine Humans Tibial nerve Ulnar nerve Ulnar Nerve POEMS syndrome Aged Retrospective Studies M protein and skin changes syndrome business.industry lcsh:R Polyradiculoneuropathy General Medicine Original Articles Middle Aged medicine.disease Median nerve Median Nerve Electrophysiology Polyradiculoneuropathy Chronic Inflammatory Demyelinating 030220 oncology & carcinogenesis POEMS Syndrome Skin Abnormalities Female medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Chinese Medical Journal, Vol 132, Iss 14, Pp 1666-1672 (2019) Chinese Medical Journal |
| ISSN: | 2542-5641 0366-6999 |
| Popis: | Background: The detection of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome at early stage is challenging for neurologists. Since polyneuropathy could be the first manifestation, it could be misdiagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP). The present study aimed to determine the clinical and electrophysiological features of POEMS syndrome to distinguish from CIDP. Methods: The data of a group of patients with POEMS (n = 17) and patients with CIDP (n = 17) in Zhongshan Hospital Fudan University from January 2015 to September 2017 were analyzed in this retrospective study. The clinical features, neurological symptoms, and electrophysiological findings were compared between the two groups. Results: Clinically, patients with POEMS demonstrated significantly more neuropathic pain in the lower extremities than patients with CIDP (58.8% vs. 11.8%, P = 0.01). Multisystem features like edema, skin change, organomegaly, and thrombocytosis were also pointed towards the diagnosis of POEMS syndrome. Electrophysiologically, terminal latency index (TLI) was significantly higher in patients with POEMS than that in patients with CIDP (median nerve: 0.39 [0.17–0.52] vs. 0.30 (0.07–0.69), Z = –2.413, P = 0.016; ulnar nerve: 0.55 [0.23–0.78] vs. 0.42 [0.12–0.70], Z = –2.034, P = 0.042). Patients with POEMS demonstrated a higher frequency of absent compound muscle action potential of the tibial nerve (52.9% vs. 17.6%, P = 0.031), less conduction block (ulnar nerve: 0 vs. 35.3%, P = 0.018), and less temporal dispersion (median nerve: 17.6% vs. 58.8%, P = 0.032) than CIDP group. The combination of positive serum monoclonal protein and high TLI (if either one or both were present) discriminated POEMS from CIDP with a sensitivity of 94.1% and 47.1% and specificity of 76.5% and 100.0%, respectively. Conclusions: POEMS syndrome could be distinguished from CIDP through typical clinical and electrophysiological characteristics in practice. The combination of serum monoclonal protein and high TLI might raise the sensitivity of detecting POEMS syndrome. Key words: Polyneuropathy; Organomegaly; Endocrinopathy; M protein and skin changes syndrome; Chronic inflammatory demyelinating polyradiculoneuropathy; Terminal latency index |
| Databáze: | OpenAIRE |
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