The Association between HL-A Antigens, Ankylosing Spondylitis and Sacro-Iliitis
| Autor: | P. J. Rooney, HeatherM. Dick, W. W. Buchanan, B. Canesi, R. D. Sturrock, G. K. Goel, Neil Henderson, W C Dick |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Adolescent Genotype Immunology Hl a antigens Disease Biochemistry Family studies Antigen HLA Antigens Histocompatibility Antigens Genetics medicine Humans Immunology and Allergy Spondylitis Ankylosing Child Ankylosing spondylitis business.industry Histocompatibility Testing Sacroiliac Joint General Medicine Middle Aged medicine.disease Clinical disease Arthritis Juvenile Pedigree Female business Juvenile rheumatoid arthritis |
| Zdroj: | Tissue Antigens. 5:26-32 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1975.tb00522.x |
| Popis: | The second series antigen W27 has been found to have an increased frequency in ankylosing spondylitis (82 per cent of 17 patients) and juvenile rheumatoid arthritis (Still's disease) (29 per cent of 24 patients). Three family studies are presented, including one in which the antigen W27 occurs both in the absence and the presence of ankylosing spondylitis. It is suggested that this family illustrates that the relationship between W27 and sacro-iliitis is affected by non-HL-A genes. The development of clinical disease depends upon the coincidence of several factors in one individual, some of which are genetically controlled by two or more loci which are not necessarily linked. |
| Databáze: | OpenAIRE |
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