Synthesis of an advanced intermediate for (+)-pillaromycinone. Staunton-Weinreb annulation revisited
| Autor: | Qing Xu, William H. C. Martin, F. W. J. Demnitz, James D. White |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Annulation
Pillaromycinone Magnetic Resonance Spectroscopy Molecular Structure Organic Chemistry Condensation Substituent Hydroxylation Biochemistry chemistry.chemical_compound chemistry Computational chemistry Organic chemistry Anthracyclines Physical and Theoretical Chemistry Organic Chemicals Derivative (chemistry) |
| Zdroj: | Organic letters. 10(13) |
| ISSN: | 1523-7060 |
| Popis: | Condensation of an orsellinate anion with a 2-cyclohexenone (Staunton−Weinreb annulation) afforded a linear tetracycle which was converted to a protected derivative of 12a-epipillaromycinone. Methodology for introducing a 12a-hydroxyl substituent into the tetracycle with correct (R) configuration is described. |
| Databáze: | OpenAIRE |
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