Subzonal insertion of multiple sperm is a treatment for male factor infertility
| Autor: | Urszula B. Krzyminska, Chris O'Neill, JP Ryan, Elizabeth Csehi, Liza Tilia, James W. Catt, IL Pike |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Semen Fertilization in Vitro Biology Cryopreservation Group B Andrology Micromanipulation Human fertilization Pregnancy medicine Humans Infertility Male Zona Pellucida Gynecology Sperm-Ovum Interactions Pregnancy Outcome Obstetrics and Gynecology Embryo medicine.disease Embryo Transfer Sperm Pregnancy rate Reproductive Medicine Female |
| Zdroj: | Fertility and sterility. 61(1) |
| ISSN: | 0015-0282 |
| Popis: | Objective To determine whether subzonal insemination of multiple sperm is an effective treatment for male factor infertility. Design Subzonal insemination by micromanipulation of sperm and oocytes for male factor patients. Patients Two hundred eight patients were selected on previous fertilization history and/or semen parameters. They could be assigned to one of three groups: group A had previous IVF failure, group B had a low fertilization rate with previous IVF, and group C had insufficient sperm for IVF. Interventions Oocytes were inseminated by subzonal insertion of multiple sperm. Main Outcome Measures Fertilization and pregnancy rates. Results There have been 208 patients treated through 332 treatment cycles. Of 2,789 oocytes inseminated, 784 oocytes were fertilized (28%) and 516 of these (66%) were monospermic. This represents normal fertilization in 207cycles (62% of total patient cycles). These 207cycles produced an average of 2.6±1.8 embryos. The resultant 487 embryos were either transferred or cryopreserved for future transfer. A total of 42 pregnancies (21% per ET) resulted from 200 ET procedures with 397 embryos. Miscarriages or elective terminations have occurred (11/42 pregnancies, 26% to date) and 21 deliveries have resulted in 26 babies. There are nine ongoing pregnancies. Three of the pregnancies have been from cryopreserved embryos. Group B patients had the highest fertilization rate (23%) but the lowest pregnancy rate (7%). No other significant relationships between patient group and outcome were found. Conclusions Subzonal insemination of multiple sperm is an effective treatment for some forms of male factor infertility. |
| Databáze: | OpenAIRE |
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