Phytoestrogens and Breast Cancer Prevention: Possible Mechanisms of Action

Autor: Hari K. Bhat, Tom K. Hei, Ramesh K. Ganju, Sarah M. Mense
Rok vydání: 2008
Předmět:
endocrine system
cytochrome P450
catechol-O-methyltransferase
Health
Toxicology and Mutagenesis
Estrogen receptor
Breast Neoplasms
Phytoestrogens
Review
Cell Enlargement
Pharmacology
Bioinformatics
03 medical and health sciences
chemistry.chemical_compound
Aromatase
breast cancer
0302 clinical medicine
Breast cancer
Cytochrome P-450 Enzyme System
Risk Factors
estrogen
Animals
Anticarcinogenic Agents
Humans
chemoprevention
Medicine
Estrogen Metabolism
Cell Proliferation
030304 developmental biology
0303 health sciences
urogenital system
business.industry
Public Health
Environmental and Occupational Health
food and beverages
Estrogens
medicine.disease
Diet
3. Good health
Catechol estrogen
Receptors
Estrogen
Action (philosophy)
chemistry
030220 oncology & carcinogenesis
catechol estrogen
phytoestrogen
business
Signal Transduction
estrogen receptor
Zdroj: Environmental Health Perspectives
ISSN: 1552-9924
0091-6765
DOI: 10.1289/ehp.10538
Popis: Objective Phytoestrogens display an array of pharmacologic properties, and in recent years investigation of their potential as anticancer agents has increased dramatically. In this article we review the published literature related to phytoestrogens and breast cancer as well as suggest the possible mechanisms that may underlie the relationship between phytoestrogens and breast cancer. Data sources Electronic searches on phytoestrogens and breast cancer were performed on MEDLINE and EMBASE in June 2007. No date restriction was placed on the electronic search. Data extraction We focused on experimental data from published studies that examined the characteristics of phytoestrogens using in vivo or in vitro models. We also include human intervention studies in this review. Data synthesis We evaluated evidence regarding the possible mechanisms of phytoestrogen action. Discussions of these mechanisms were organized into those activities related to the estrogen receptor, cell growth and proliferation, tumor development, signaling pathways, and estrogen-metabolizing enzymes. Conclusions We suggest that despite numerous investigations, the mechanisms of phytoestrogen action in breast cancer have yet to be elucidated. It remains uncertain whether these plant compounds are chemoprotective or whether they may produce adverse outcomes related to breast carcinogenesis.
Databáze: OpenAIRE
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