Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire
| Autor: | Raymond C. Rosen, Rogerio A. Lobo, Hwa Ming Yang, Barbara A. Block, Roland Gerritsen van der Hoop |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Sexual Behavior Administration Oral chemistry.chemical_compound Sex hormone-binding globulin Double-Blind Method Internal medicine Methyltestosterone medicine Humans Testosterone Aged biology business.industry Obstetrics and Gynecology Testosterone (patch) Estrogens Middle Aged medicine.disease Menopause Esterified estrogen Sexual desire Endocrinology Reproductive Medicine chemistry Estrogen biology.protein Drug Therapy Combination Female Sexual function business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Fertility and sterility. 79(6) |
| ISSN: | 0015-0282 |
| Popis: | Objective In some women, a decline in sexual interest accompanies a relative androgen insufficiency after menopause. We sought to characterize the hormonal effects of the combination of oral esterified estrogens and methyltestosterone and to investigate whether this regimen improves hypoactive sexual desire. Design Double-blind randomized trial. Setting Healthy volunteers in a multicenter research environment. Patient(s) Postmenopausal women taking estrogen therapy who were experiencing hypoactive sexual desire. Intervention(s) 4 months of treatment with 0.625 mg of esterified estrogens (n = 111) or the combination of 0.625 mg of esterified estrogens and 1.25 mg of methyltestosterone (n = 107). Main outcome measure(s) Baseline and end-of-study measurements of total and bioavailable testosterone and sex hormone–binding globulin (SHBG), and mean change in level of sexual interest or desire as rated on the Sexual Interest Questionnaire. Result(s) Treatment with the combination of esterified estrogens and methyltestosterone significantly increased the concentration of bioavailable testosterone and suppressed SHBG. Scores measuring sexual interest or desire and frequency of desire increased from baseline with combination treatment and were significantly greater than those achieved with esterified estrogens alone. Treatment with the combination was well tolerated. Conclusion(s) Increased circulating levels of unbound testosterone and suppression of SHBG provide a plausible hormonal explanation for the significantly improved sexual functioning in women receiving the combination of esterified estrogen and methyltestosterone. |
| Databáze: | OpenAIRE |
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