Chromosome sensitivity to bleomycin-induced mutagenesis in lymphocytes from colorectal cancer patients under 40 years of age
| Autor: | Zvi Fireman, Fiorella Shabtai, Benjamin Lurie |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Colorectal cancer Lymphocyte Matched-Pair Analysis Adenocarcinoma Bleomycin Gastroenterology chemistry.chemical_compound Surgical oncology Internal medicine medicine Chromosomes Human Humans Lymphocytes Young adult Chromosome Aberrations business.industry Rectal Neoplasms Chromosome Fragility General Medicine medicine.disease Colorectal surgery medicine.anatomical_structure chemistry Colonic Neoplasms Female business Mutagens |
| Zdroj: | Diseases of the colon and rectum. 37(12) |
| ISSN: | 0012-3706 |
| Popis: | PURPOSE: The incidence of colorectal cancer in young adults (under 40 years of age) is rare. The reason for the occurrence in these patients may lie in their genetic background. METHODS: We studied chromosomal fragility in peripheral blood lymphocytes of patients under the age of 40 with large bowel cancer. Lymphocytes from 24 subjects were examined: 10 untreated large bowel cancer patients under the age of 40 and 14 age-matched and sex-matched controls. RESULTS: The mean number of spontaneous chromosomal breaks per cells (b/c) was significantly higher in the right-sided large bowel cancer patients (0.23±0.12 b/c) compared with the control group (0.09±0.04 b/c;P |
| Databáze: | OpenAIRE |
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