Impact of Negative Symptoms on Functioning and Quality of Life in First Psychotic Episodes of Schizophrenia

Autor: Lorena García-Fernández, Verónica Romero-Ferreiro, Luis Sánchez-Pastor, Mónica Dompablo, Isabel Martínez-Gras, Juan Manuel Espejo-Saavedra, David Rentero, Ana Isabel Aparicio, Miguel Angel Alvarez-Mon, Guillermo Lahera, Jimmy Lee, Jose Luis Santos, Roberto Rodriguez-Jimenez
Přispěvatelé: Lee Kong Chian School of Medicine (LKCMedicine)
Rok vydání: 2022
Předmět:
Zdroj: E-Prints Complutense. Archivo Institucional de la UCM
Universidad Europea (UEM)
Journal of Clinical Medicine
Volume 11
Issue 4
Pages: 983
ABACUS. Repositorio de Producción Científica
ISSN: 2077-0383
Popis: Negative symptoms are not considered a unitary construct encompassing two different domains, diminished expression, and avolition-apathy. The aim of this study was to explore the relationships between each domain and psychosocial functioning and quality of life in people with a first psychotic episode of schizophrenia. In total, 61 outpatients were assessed with the Clinical Assessment Interview for Negative Symptoms (CAINS), The Functioning Assesment Short Test (FAST) and The Quality of Life Scale (QLS). The mean global score for CAINS was 21.5 (SD: 15.6), with a CAINS Avolition-Apathy (MAP) score of 17.0 (SD: 11.8), and CAINS Diminished Expression (EXP) score of 4.5 (SD: 5.0). The mean FAST score was 31.9 (SD: 18.9), and 41.1 (SD: 17.9) for QLS. Linear regression analysis revealed a significant (F(4,53) = 15.65, p < 0.001) relationship between MAP and EXP CAINS' score and FAST score. CAINS-MAP was more predictive of FAST scores (β = 0.44, p = 0.001) than CAINS-EXP (β = 0.37, p = 0.007). Linear regression analysis for QLS revealed a significant model (F(4,56) = 29.29, p < 0.001). The standardized regression weight for the CAINS-MAP was around three times greater (β = -0.63, p < 0.001) than for CAINS-EXP (β = -0.24, p = 0.024). The two different domains are associated differently with functionality and quality of life. Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This research was supported in part by the by the Instituto de Salud Carlos III (grants PI16/00359, PI19/00766; Fondo de Investigaciones Sanitarias/FEDER), by the European Development Regional Fund “A way to achieve Europe” (ERDF), by Madrid Regional Government (R&D activities in Biomedicine S2017/BMD-3740 (AGES cm 2-CM)) and Structural Funds of the European Union. JL was supported by the Singapore Ministry of Health National Medical Research Council Clinician Scientist Award (MOH-000013).
Databáze: OpenAIRE
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