Metastasis of Rous Sarcoma Tumors in Chickens is Influenced by the Major Histocompatibility (B) Complex and Sex
| Autor: | R. W. Fite, W. M. Collins, W. R. Dunlop, R. W. Briles, Robert M. Zsigray |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Sarcoma Avian Rous sarcoma virus Inoculation General Medicine Biology medicine.disease biology.organism_classification Major histocompatibility complex Virology Metastasis Major Histocompatibility Complex Lesion B vitamins Sex Factors Inbred strain medicine biology.protein Animals Female Animal Science and Zoology Neoplasm Metastasis medicine.symptom Chickens Major histocompatibility |
| Zdroj: | Poultry Science. 65:1642-1648 |
| ISSN: | 0032-5791 |
| DOI: | 10.3382/ps.0651642 |
| Popis: | Six-week-old second generation progeny from the cross of inbred Lines 61 and 151, segregating into three major histocompatibility (B) complex groups (B2/B2, B2/B5, and B5/B5). were inoculated subcutaneously in the wingweb with one of three pseudotypes of Rous sarcoma virus. Chickens that died during a 10-week period after inoculation were necropsied and scrutinized for gross metastasis and histological sections of at least one lesion per affected organ examined for Rous sarcoma-transformed cells, By definition, a metastatic tumor was one located in an organ or tissue other than the primary inoculation site and having the histological appearance of a Rous sarcoma. Sarcomas developed in 1144 chickens, 390 of which died with tumor. For B2/B2, compared to B5/B5 hosts, mortality was 8 vs. 93%, median days to death were 45 vs. 31, and metastatic frequency was significantly lower, 32 vs. 58%. Disseminated lesions were significantly less frequent in females than males and grew preferentially in the heart and pericardial sac. Because the frequency of metastasis was significanlty lower in B2/B2 than in B5/B5 chickens, a gene(s) within, or closely linked to, the B complex sharply retards the spread of Rous sarcoma virus-induced tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|