The functional anatomy of divided attention in amnestic mild cognitive impairment
| Autor: | Sukhwinder S. Shergill, Zuzana Walker, Tim Stevens, Thomas Dannhauser, Marc L. Seal, Lean Lee |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Prefrontal Cortex Neuropsychological Tests behavioral disciplines and activities Neuroimaging Alzheimer Disease mental disorders Reaction Time medicine Humans Memory impairment Dementia Attention Prefrontal cortex Episodic memory Aged Visual Cortex Aged 80 and over Brain Mapping medicine.diagnostic_test Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Acoustic Stimulation Disease Progression Female Amnesia Neurology (clinical) Alzheimer's disease Cognition Disorders Functional magnetic resonance imaging Psychology Neuroscience Photic Stimulation |
| Zdroj: | Brain. 128:1418-1427 |
| ISSN: | 1460-2156 0006-8950 |
| DOI: | 10.1093/brain/awh413 |
| Popis: | Recent neuroimaging studies have demonstrated changes in brain function in cognitively normal subjects at increased risk of developing Alzheimer's disease. Amnestic mild cognitive impairment (AMCI) carries a high risk of developing into Alzheimer's disease. In AMCI altered cortical activation has been demonstrated during memory tasks, using functional MRI (fMRI). Memory and attention are closely related cognitive functions. It is unclear whether the memory impairment of AMCI is associated with attentional deficits of the sort likely to be revealed by tasks requiring divided attention. Ten older adults (mean age 72 years, range 57-81 years) with AMCI were compared with healthy matched controls on divided attention and passive sensory processing tasks using fMRI. During the divided attention task both groups activated similar regions of left hemispheric prefrontal and extrastriate visual cortex. However, the AMCI group had attenuated prefrontal activation compared with age matched controls. On the passive sensory processing task there was no difference between the AMCI and control groups. We conclude that there are changes in the functional network subserving divided attention in patients with AMCI as reflected in the attenuation of prefrontal cortical activation. These findings have implications for evaluating cognition in AMCI and also for monitoring the effects of future treatments in AMCI. |
| Databáze: | OpenAIRE |
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