Development and Validation of Optical Methods for Zeta Potential Determination of Silica and Polystyrene Particles in Aqueous Suspensions
| Autor: | Gert Roebben, Vikram Kestens, Yannic Ramaye, Marta Dabrio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
particle tracking analysis Analytical chemistry Context (language use) 02 engineering and technology 010402 general chemistry lcsh:Technology 01 natural sciences Article electrophoretic light scattering Colloid chemistry.chemical_compound zeta potential measurement uncertainty Zeta potential General Materials Science lcsh:Microscopy reference material lcsh:QC120-168.85 lcsh:QH201-278.5 lcsh:T method validation Repeatability 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry silica lcsh:TA1-2040 Measurement uncertainty Particle lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering Polystyrene Electrophoretic light scattering lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology lcsh:TK1-9971 |
| Zdroj: | Materials Materials, Vol 14, Iss 290, p 290 (2021) Materials; Volume 14; Issue 2; Pages: 290 |
| ISSN: | 1996-1944 |
| Popis: | Zeta potential is frequently used to examine the colloidal stability of particles and macromolecules in liquids. Recently, it has been suggested that zeta potential can also play an important role for grouping and read-across of nanoforms in a regulatory context. Although the measurement of zeta potential is well established, only little information is reported on key metrological principles such as validation and measurement uncertainties. This contribution presents the results of an in-house validation of the commonly used electrophoretic light scattering (ELS) and the relatively new particle tracking analysis (PTA) methods. The performance characteristics were assessed by analyzing silica and polystyrene reference materials. The ELS and PTA methods are robust and have particle mass working ranges of 0.003 mg/kg to 30 g/kg and 0.03 mg/kg to 1.5 mg/kg, respectively. Despite different measurement principles, both methods exhibit similar uncertainties for repeatability (2%), intermediate precision (3%) and trueness (4%). These results confirm that the developed methods can accurately measure the zeta potential of silica and polystyrene particles and can be transferred to other laboratories that analyze similar types of samples. If direct implementation is impossible, the elaborated methodologies may serve as a guide to help laboratories validating their own methods. |
| Databáze: | OpenAIRE |
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