Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units
| Autor: | Alexander V. Chernyak, Jan Balzarini, Vyacheslav M. Martynenko, Pavel A. Troshin, Dominique Schols, Ilya I. Voronov |
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| Rok vydání: | 2018 |
| Předmět: |
Fullerene
Anti-HIV Agents Polymers Carboxylic Acids Ionic bonding Bioengineering Microbial Sensitivity Tests 02 engineering and technology Chlorobenzenes 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry law.invention Dichlorobenzene chemistry.chemical_compound Magazine law Humans Molecule Molecular Biology Cells Cultured Molecular Structure Water Biological activity General Chemistry General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Water soluble Malonate Solubility chemistry HIV-2 HIV-1 Molecular Medicine Fullerenes 0210 nano-technology Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Chemistry & Biodiversity. 15:e1800293 |
| ISSN: | 1612-1872 |
| DOI: | 10.1002/cbdv.201800293 |
| Popis: | We have synthesized a series of water-soluble polycarboxylic derivatives of [60]fullerene with a gradually changed polarity by combining three to five polar (ionic) malonate addends with two to zero hydrophobic dichlorobenzene units and explored their antiviral activity. It has been shown that decreasing the number of the ionogenic carboxylic groups in the molecules enhanced their antiviral activity against HIV-1 and suppressed their action against HIV-2. The obtained results implied that the charged states and hydrophobicity of the water-soluble polycarboxylic fullerene derivatives affect significantly their biological properties. |
| Databáze: | OpenAIRE |
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