Evoked potential (EP) alterations in experimental allergic encephalomyelitis (EAE): early delays and latency reductions without plaques
| Autor: | Domenico Gambi, Marco Onofrj, D. Melchionda, T. Fulgente |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Encephalomyelitis Guinea Pigs Dermatology law.invention Myelin law Reaction Time medicine Animals Remyelination Evoked potential Evoked Potentials Chemistry General Neuroscience Multiple sclerosis General Medicine medicine.disease Disease Models Animal Psychiatry and Mental health medicine.anatomical_structure Somatosensory evoked potential Neurology (clinical) Brainstem Electron microscope Neuroscience Demyelinating Diseases |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1590-3478 0392-0461 |
| Popis: | Experimental allergic encephalomyelitis (EAE) in its chronic relapsing (CR-EAE), chronic progressive (CP-EAE) and acute (A-EAE) forms was obtained in 24 juvenile strain 13 guinea pigs. Visual, brainstem acoustic and somatosensory evoked potentials (EPs) were recorded in these animals prior to the sensitizing injection and during the course of the disease. Delays in the EPs appeared 15 days post-sensitization (dps), preceding or simultaneously with clinical alterations: electron microscopy revealed myelin stripping and vacuolation in the animals sacrificed 25 dps. Decreases in EP latency were recorded 32 dps; when electron microscopy revealed myelin layers indicating remyelination, whereas light microscopy showed only inflammatory changes. When confluent plaques were revealed by light microscopy 120 dps, the EP wave shapes were distorted or absent. The discussion reviews the literature on early myelin and conduction changes during central demyelination. |
| Databáze: | OpenAIRE |
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