Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
| Autor: | Marieke M. L. Rich, Jurriaan H. de Groot, J.H. Arendzen, Jasper Schuurmans, Alfred C. Schouten, Carel G. M. Meskers |
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| Přispěvatelé: | Rehabilitation medicine, Amsterdam Neuroscience - Neurovascular Disorders, Amsterdam Movement Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Reflex Stretch Time Factors EMG flexor carpi radialis M2 reflex tizanidine Neuroscience(all) Flexor carpi radialis muscle Administration Oral Electromyography Affect (psychology) M2 response Clonidine Forearm Evoked Potentials Somatosensory medicine Humans Attention Stretch reflex Muscle Skeletal Probability Tizanidine medicine.diagnostic_test General Neuroscience II aVerent M2 response II afferent Stretch reflex Tizanidine ii muscle afferents electromyographic responses spinal interneurons biceps muscle human wrist reflex transmission pathways humans input Parasympatholytics Middle Aged Stretch reXex medicine.anatomical_structure Duration (music) Anesthesia METIS-270125 Linear Models II afferent Female Psychology medicine.drug Research Article |
| Zdroj: | Experimental Brain Research, 201(4), 681-688. Springer Verlag Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale Experimental Brain Research, 201(4), 681-688 Meskers, C G M, Schouten, A C, Rich, M M L, De Groot, J H, Schuurmans, J & Arendzen, J H 2010, ' Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis ', Experimental Brain Research, vol. 201, no. 4, pp. 681-688 . https://doi.org/10.1007/s00221-009-2085-x Experimental brain research, 201 (4), 2010 Experimental brain research, 201(4), 681-688. Springer Experimental Brain Research, 201(4), 681-8 |
| ISSN: | 0014-4819 1432-1106 |
| Popis: | The long latency M2 electromyographic response of a suddenly stretched active muscle is stretch duration dependent of which the nature is unclear. We investigated the influence of the group II afferent blocker tizanidine on M2 response characteristics of the m. flexor carpi radialis (FCR). M2 response magnitude and eliciting probability in a group of subjects receiving 4 mg of tizanidine orally were found to be significantly depressed by tizanidine while tizanidine did not affect the significant linear relation of the M2 response to stretch duration. The effect of tizanidine on the M2 response of FCR is supportive of a group II afferent contribution to a compound response of which the stretch duration dependency originates from a different mechanism, e.g., rebound Ia firing. |
| Databáze: | OpenAIRE |
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