Brain magnetic resonance imaging features in multiple sclerosis and neuromyelitis optica spectrum disorders patients with or without aquaporin-4 antibody in a Latin American population
| Autor: | Facundo Silveira, Carolina Lavigne Moreira, Liliana Patrucco, Francisco Sánchez, Agustín Pappolla, Verónica Tkachuk, Edgar Carnero Contentti, Ibis Soto de Castillo, Maria C Castillo, Antonio Carlos dos Santos, Vanessa Daccach Marques, Alejandro Caride, Camila de Aquino Cruz, Juan Ignacio Rojas, Juan Pablo Pettinicchi, Gabriel Braga Diégues Serva, Pablo A. López, Omaira Molina, Edgardo Cristiano |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Population Argentina Neuroimaging Lesion 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine education Autoantibodies Retrospective Studies Aquaporin 4 education.field_of_study medicine.diagnostic_test business.industry Medical record Multiple sclerosis Neuromyelitis Optica Brain Magnetic resonance imaging General Medicine medicine.disease Venezuela Magnetic Resonance Imaging Neurology Aquaporin-4 antibody Neuromyelitis Optica Spectrum Disorders Cohort Female Neurology (clinical) Radiology medicine.symptom Atrophy business 030217 neurology & neurosurgery Brazil Follow-Up Studies |
| Zdroj: | Multiple sclerosis and related disorders. 42 |
| ISSN: | 2211-0356 |
| Popis: | INTRODUCTION There is scarce evidence comparing the behavior in magnetic resonance (MRI) between positive and negative aquaporin-4 antibody neuromyelitis optica spectrum disorders (P-NMOSD and NNMOSD, respectively). The aim of this study was to describe and compare MRI features through a quantitative and qualitative analysis between P-NMOSD and NNMOSD patients in a cohort from Latin American (LATAM) patients. METHODS We retrospectively reviewed the MRI and medical records of NMOSD patients as defined by the 2015 validated diagnostic criteria, and with at least 3 years of follow-up from disease onset (first symptom). We included patients from Argentina, Brazil and Venezuela. To be included, NMOSD patients must have had AQP4-ab status measured by a cell-based assay. Brain MRIs were obtained for each participant at disease onset and every 12 months for 3 years. Demographics, clinical and MRI variables (T2 lesion volume [T2LV], lesion distribution, cortical thickness [CT] and percentage of brain volume loss [PBVL]) were analyzed and compared between groups (P-NMOSD; NNMOSD) at disease onset and follow-up. A multiple sclerosis (MS) control group of patients was also included. RESULTS We included 24 P-NMOSD, 15 NNMOSD and 35 MS patients. No differences in age, gender and follow-up time were observed between groups. Nor were differences found in lesion distribution at disease onset or in brain volumes during follow-up between P-NMOSD and NNMOSD patients (T2LV = 0.43, CT = 0.12, PBVL p = 0.45). Significant differences were observed in lesion distribution at disease onset, as well as in brain volumes during follow-up between NMOSD and MS (T2LV = p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect