Association of preoperative plasma fibrinogen level with postoperative bleeding after on-pump coronary bypass surgery: does plasma fibrinogen level affect the amount of postoperative bleeding?
| Autor: | Sadi Kaplan, Murat Songur, Sameh Alagha, Kerem M. Vural, Tugba Avci |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Excessive Bleeding Coronary Artery Disease Postoperative Hemorrhage 030204 cardiovascular system & hematology Fibrinogen Preoperative care law.invention 03 medical and health sciences Coronary artery bypass surgery 0302 clinical medicine Risk Factors 030202 anesthesiology law medicine Cardiopulmonary bypass Humans Coronary Artery Bypass Hemostatic function Retrospective Studies Cardiopulmonary Bypass Platelet Count business.industry Middle Aged Hemostatics Bypass surgery Anesthesia Preoperative Period Female Surgery Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Interactive CardioVascular and Thoracic Surgery. 27:671-676 |
| ISSN: | 1569-9285 1569-9293 |
| Popis: | OBJECTIVES Our primary aim was to investigate the association between the preoperative concentration of plasma fibrinogen and the volume of postoperative bleeding. Our secondary aim was to identify whether there is a possible correlation between the patients' different characteristics and haemostatic laboratory variables and the postoperative amount of bleeding after on-pump coronary artery bypass grafting procedures. METHODS A total of 550 adult patients undergoing isolated coronary artery bypass grafting on cardiopulmonary bypass in our hospital were enrolled and investigated retrospectively. The total amount of chest tube drainage within the first 24 postoperative hours or until the patient was re-explored for bleeding was assessed. Excessive bleeding was defined as more than 500 ml drainage in the first 24 h. The patients were divided into 2 groups: Group 1: the patients who bled ≤500 ml in the first 24 h and Group 2: the patients who bled >500 ml in the first 24 h. RESULTS A preoperative fibrinogen threshold associated with excessive bleeding was investigated by receiver operating characteristic curve analyses, revealing a calculated cutoff value of 3.1 g/l. Risk factors for increased bleeding were analysed by a logistic regression model that revealed male gender (P |
| Databáze: | OpenAIRE |
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