Effects of Aldosterone and Betamethasone on Na-K-ATPase Activity in the Juxtamedullary Proximal Convoluted Tubules of Mice
| Autor: | Akio Furuse |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Cell Betamethasone Steroid Kidney Tubules Proximal Cell membrane Mice chemistry.chemical_compound Internal medicine medicine Animals Na+/K+-ATPase Aldosterone biology business.industry Cell Membrane Enzyme assay medicine.anatomical_structure Endocrinology chemistry Pediatrics Perinatology and Child Health biology.protein Sodium-Potassium-Exchanging ATPase business medicine.drug Hormone |
| Zdroj: | Pediatrics International. 31:1-6 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/j.1442-200x.1989.tb01261.x |
| Popis: | An attempt was made to determine whether or not the steroid hormones, aldosterone and betamethasone, increased the Na-K-ATPase activity and the surface density of baso-lateral cell membranes in the juxtamedullary proximal convoluted tubules of young and adult mice. The results showed that aldosterone and betamethasone increase the enzyme activity in young mice but not in adult mice. However, the surface density of the baso-lateral cell membranes did not increase either in the young or in the adult mice. Further, the induction ratio for the Na-K-ATPase activity did not differ between the two hormone-treated groups in young mice. The results suggest that a difference in hormone sensitivity exists between the proximal convoluted tubular cells of young mice and those of adult mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text