Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial

Autor: Montserrat Fitó, Jose R Fernandez-Navarro, María Roca, Miguel Angel Calleja, Emilio Martínez de Victoria, Angel Gil, Juan Antonio Espejo-Calvo, Blas Gil-Extremera, Sara Biel-Glesson, Estefania Sanchez-Rodriguez, María Trinidad Soria-Florido, María D. Mesa, Juan de Dios Alché, Elena Lima-Cabello, Rafael de la Torre, María-Isabel Covas
Přispěvatelé: Centro para el Desarrollo Tecnológico Industrial (España), Junta de Andalucía
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Adult
Male
Phytochemicals
030204 cardiovascular system & hematology
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Double-Blind Method
Phenols
Maslinic acid
In vivo
Virgin olive oil
medicine
Humans
Food science
Oleanolic acid
030109 nutrition & dietetics
Nutrition and Dietetics
Cross-Over Studies
Endothelin-1
Cholesterol
olive oil
virgin olive oil
olive oil polyphenols
maslinic acid
oleanolic acid
cardiovascular diseases
endothelial function
phenolic compounds
triterpenes
metabolic syndrome
Cholesterol
HDL
Endothelial function
Middle Aged
medicine.disease
Metabolic syndrome
Bioactive compound
Phenolic compounds
Triterpenes
Olive oil polyphenols
Cardiovascular diseases
chemistry
Dietary Supplements
Food
Fortified
Female
Endothelium
Vascular
Energy Intake
Ex vivo
Biomarkers
Olive oil
Food Science
Zdroj: Recercat. Dipósit de la Recerca de Catalunya
instname
Nutrients
Digibug. Repositorio Institucional de la Universidad de Granada
Nutrients; Volume 10; Issue 5; Pages: 626
Digital.CSIC. Repositorio Institucional del CSIC
Popis: 17 Páginas; 3 Figuras; 5 Tablas
The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a three-week randomized, crossover, controlled, double-blind, intervention study involving 58 subjects supplemented with a daily dose (30 mL) of three oils: (1) a VOO (124 ppm of phenolic compounds and 86 ppm of triterpenes); (2) an optimized VOO (OVOO) (490 ppm of phenolic compounds and 86 ppm of triterpenes); and (3) a functional olive oil (FOO) high in phenolic compounds (487 ppm) and enriched with triterpenes (389 ppm). Metabolic syndrome and endothelial function biomarkers were determined in vivo and ex vivo. Plasma high density lipoprotein cholesterol (HDLc) increased after the OVOO intake. Plasma endothelin-1 levels decreased after the intake of the three olive oils, and in blood cell cultures challenged. Daily intake of VOO enriched in phenolic compounds improved plasma HDLc, although no differences were found at the end of the three interventions, while VOO with at least 124 ppm of phenolic compounds, regardless of the triterpenes content improved the systemic endothelin-1 levels in vivo and ex vivo. No effect of triterpenes was observed after three weeks of interventions. Results need to be confirmed in subjects with metabolic syndrome and impaired endothelial function (Clinical Trials number NCT02520739).
The “NUTRAOLEUM Study” has been supported by the grant ITC-20131031 from the I+D FEDER-INTERCONNECTA (CDTI) and Junta de Andalucía, Spain”. We thank ACER CAMPESTRES S.L., SAN FRANCISCO DE ASIS Coop and AGROINSUR S.L., for the funding provided. The authors thank Pilar Jiménez, Alberto Guarnido, María Molina and Elizabeth García for administering the questionnaires to the subjects; Isabel Mérida, Isabel Hinojosa, Agustín Martín García, and María Luz Abarca for collecting the biological samples; and Victoria Martín Laguna and Laura Campaña Martín for aliquoting the samples. The authors also thank María Cruz Rico Prados for sample analysis and Llenalia M. García Fernández for her contributions to the statistical analysis.
Databáze: OpenAIRE
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