Sleep modulates hypertension in leptin-deficient obese mice
| Autor: | Chiara Berteotti, Viviana Lo Martire, Alessandro Silvani, Pierluigi Lenzi, Giovanna Zoccoli, Stefano Bastianini, Carlo Franzini |
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| Přispěvatelé: | Silvani A., Bastianini S., Berteotti C., Franzini C., Lenzi P., Lo Martire V., Zoccoli G. |
| Rok vydání: | 2008 |
| Předmět: |
Leptin
Male medicine.medical_specialty Sleep REM Blood Pressure Mice Internal medicine Heart rate Internal Medicine Medicine Animals Obesity Wakefulness Obese Mice business.industry medicine.disease Sleep in non-human animals Mice Mutant Strains Disease Models Animal Mean blood pressure Blood pressure Endocrinology Codon Nonsense Hypertension business Sleep |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 53(2) |
| ISSN: | 1524-4563 |
| Popis: | Leptin increases sympathetic activity, possibly contributing to hypertension in obese subjects. Hypertension increases cardiovascular mortality, with nighttime (sleep) blood pressure having a substantial prognostic value. We measured blood pressure in male leptin-deficient obese mice (ob/ob; n=7) and their lean wild-type littermates (+/+; n=11) during wakefulness, non–rapid-eye-movement sleep, and rapid-eye-movement sleep to investigate whether, in the absence of leptin, derangements of blood pressure are still associated with obesity and depend on the wake-sleep state. Mice were implanted with a telemetric pressure transducer and electrodes for discriminating wake-sleep states. Mean blood pressure was significantly higher in ob/ob than in +/+ mice during wakefulness (7.3±2.6 mm Hg) and non–rapid-eye-movement sleep (6.7±2.8 mm Hg) but not during rapid-eye-movement sleep (2.6±2.6 mm Hg). In ob/ob and +/+ mice, mean blood pressure was substantially higher during wakefulness than during non–rapid-eye-movement sleep. On passing from non–rapid-eye-movement sleep to rapid-eye-movement sleep, mean blood pressure decreased significantly in ob/ob but not in +/+ mice. The time spent during wakefulness was lower in ob/ob than in +/+ mice during the dark (active) period, whereas the opposite occurred during the light (rest) period. Consequently, mean blood pressure was significantly higher in ob/ob than in +/+ mice during the light (8.2±2.4 mm Hg) but not during the dark (3.0±2.9 mm Hg) period. These data suggest that, in the absence of leptin, obesity may entail hypertensive derangements of blood pressure, which are substantially modulated by the cardiovascular effects of the wake-sleep states. |
| Databáze: | OpenAIRE |
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