The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors
| Autor: | Sherene M. Shenouda, Naomi M. Hamburg, Mustali M Dohadwala, Dellara F. Terry, Noyan Gokce, Joseph A. Vita, Monika Holbrook, William B. Chung |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Brachial Artery Vasodilator Agents Hypercholesterolemia Pulsatile flow Blood lipids Disease Coronary Artery Disease Risk Assessment Article Coronary artery disease Nitroglycerin Young Adult Risk Factors Internal medicine medicine.artery medicine Humans Obesity Risk factor Brachial artery Sex Distribution Aged Aged 80 and over Peripheral Vascular Diseases business.industry Vascular disease Age Factors Ultrasonography Doppler Blood flow Middle Aged medicine.disease Atherosclerosis Adaptation Physiological Endocrinology Cross-Sectional Studies Regional Blood Flow Pulsatile Flow Hypertension Cardiology Linear Models Female Stress Mechanical Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 29(4) |
| ISSN: | 1524-4636 |
| Popis: | Objective— Under physiological conditions, arteries remodel in response to changes in blood flow to maintain local shear stress. Risk factors and developing atherosclerosis may be associated with maladaptive remodeling that produces relatively large arteries with low levels of shear stress. Recent studies have shown that the brachial artery and other peripheral arteries are enlarged in patients with risk factors and cardiovascular disease, and we tested the hypothesis that this finding represents maladaptive remodeling. Methods and Results— We measured brachial artery diameter and flow by ultrasound and calculated shear stress in a diverse cohort of 1583 subjects (age 53±17 years, 62% male, and 51% with coronary artery disease and/or peripheral arterial disease). In a stepwise linear regression model, age ( P P P P =0.005), and hypercholesterolemia ( P =0.02) were associated with larger brachial diameter. Older age was associated with lower shear stress ( P Conclusions— These findings suggest that enlargement of the brachial artery in the setting of obesity, hypertension, hypercholesterolemia, and atherosclerosis reflects adaptive remodeling. The results provide further support for the concept that arterial remodeling is an important homeostatic response that is maintained despite the presence of risk factors and developing atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|