Investigation of the butyrophenone tranquilizer azaperone and its main metabolites with the Salmonella/microsome test
| Autor: | M. Scheutwinkel-Reich, I. Fülle, H.G. Grohmann, A.M. Preiss, Hans-Jürgen Stan |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Salmonella typhimurium
endocrine system Salmonella medicine.drug_class Butyrophenone Biology medicine.disease_cause Ames test Azaperone chemistry.chemical_compound Tranquilizer Species Specificity medicine Animals Biotransformation Mutagenicity Tests fungi food and beverages Rats Inbred Strains General Medicine Butyrophenones Rats Biochemistry chemistry Mutation Microsomes Liver Microsome Mutagens medicine.drug |
| Zdroj: | Mutation Research Letters. 104:339-344 |
| ISSN: | 0165-7992 |
| DOI: | 10.1016/0165-7992(82)90165-8 |
| Popis: | In previous experiments, azaperone was found to be weakly mutagenic, after metabolic activation, in the Ames assay. In this study, we subjected metabolites found in rat and swine to the Salmonella/microsome test. 5 histidine-auxotrophic strains were used. The main metabolites could be classified as weakly mutagenic substances. |
| Databáze: | OpenAIRE |
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